Matrix-assisted laser desorption/ionization (MALDI) has long been recognized as a powerful ionization method for high-molecular-weight compounds such as proteins and synthetic polymers. In reality, however, MALDI is an exceptionally versatile technique capable of ionizing analytes ranging from very small molecules with molecular weights below 100 all the way to macromolecules exceeding 100,000. What sets NewSpiralTOF™ apart is its ability to deliver clean, high-sensitivity measurements in the low-mass region, where conventional MALDI reflectron TOFMS systems often suffer from chemical noise caused by the post-source decay (PSD) fragments of matrix cluster ions. Because the SpiralTOF ion optics are built from sector electric fields, low-kinetic-energy ions generated by PSD are effectively excluded before they reach the detector. The result is a mass spectrum with virtually no chemical noise in the low-mass region, enabling highly sensitive and accurate mass measurements of small molecules.
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