UNLOCK THE ANSWERS

TO YOUR LIFE SCIENCE QUESTIONS

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  • TOMOGRAPHY IN SEM
  • High resolution 3D reconstruction
  • Maintains high level of detail through large data set
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Drosophila S2 cells thin section
Sample courtesy of Prof. Benjamin Kapek, Hope College

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Protein labeling, stereocilia and tip links
Courtesy of Corey Lab, Harvard University

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Enterobacteria phage T4

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Penium
Courtesy of Skidmore College

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3View tomography of mouse brain
– Reconstruction of axon and vesicles

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Bacteria

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Zika Virus
Inst. Microbiology/Immunology, Univ. of Ljubljana

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Montage of rabbit retina
Marc Lab, Univ. of Utah

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Human Colonic Mucosa
Janet E. Schwarz, Univ. of Vermont

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Developing spermatids in seminiferous tubule epithelium
Dr. Patrick C. Nahirney, Univ. of Victoria

Life Sciences Applications

On the forefront of a field that advances at an exhilarating speed, researchers in the life sciences need the most powerful instruments available for imaging and analysis at the nanoscale, where life begins and where living organisms interact.

JEOL TEMs are widely used in fields where transmission electron microscopy is an indispensable part of the workflow. For instance in diagnostic work, the lower kV TEMs, such as the JEM-1400, are used to identify pathologies that are crucial for proper treatment of patients. In the QC field, those same TEMs are used for analyzing products in terms of size and/or morphology. In basic research, the lower kV instruments from JEOL are sought after because of their stability and ability to quickly deliver massive amounts of data, such as that used to unravel the connectome. Yet another field is that of screening for Single Particle Workflows – here samples are evaluated before committing them to hours- or even day-long protocols on high-end, fully automated TEMs such as the JEOL CRYO ARM that can deliver three-dimensional structures of proteins and viruses at (near) atomic detail. For very Life Science Application, there is a JEOL TEMs perfectly suited for the job!

JEOL SEMs provide high resolution montages and three-dimensional images of structural details. JEOL FE-SEMs enhance imaging and throughput capabilities with image quality and resolution that rivals a TEM. An ideal tool for research and teaching facilities, the FE-SEM can be equipped with a Transmission Electron Detector, 3View Tomography and other analytical accessories.

JEOL FE-SEMs enhance imaging and throughput capabilities with image quality and resolution that rivals a TEM. An ideal tool for research and teaching facilities, the FE-SEM can be equipped with a Transmission Electron Detector, 3View Tomography and other analytical accessories.

JEOL Mass Spectrometers are used for protein characterization, proteomics, pharmaceuticals, drug development, and high throughput screening.

JEOL NMR spectrometers are used in a broad range of applications, from analysis of molecular structure, dynamics and interactions between various molecules, to fundamental material studies. Those applications are extensively used in many fields and areas, including drug research and development, structural molecular biology, development of battery technologies, food analysis and more.

Neuroscience

SEM for Neuroscience

Electron microscopy is an invaluable tool for mapping the brain for advanced neuroscience studies. The use of STEM-in-SEM (Scanning Transmission Electron Microscopy in a SEM) provides enhanced image contrast at lower voltages making it an excellent method for the characterization of thin sections of brain.

Array Tomography Using Field Emission SEM

  • High lateral resolution images
  • Automatic image acquisition
  • Large volume 3D observation
  • Large area montaging

Serial Blockface Imaging System

  • Integrated Gatan 3View System
  • 3D electron microscopy for large volumes

MALDI Imaging

MALDI Imaging with SpiralTOF Mass Spectrometer

  • Imaging and structural analysis of lipids, steroids and drug distribution directly on a brain or spinal tissue
  • Analysis of charge remote fragmentations (CRF), fragmentations particularly informative for lipids, steroids, and peptides
  • Complimentary technique to microscopy
  • 20 micron laser sampling
  • Silver Nano Particle implantation for enhanced, stable imaging
  • 75,000+ high resolution MS imaging with MS/MS confirmation
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