SuperCOOL probe

SuperCOOL probe
The SuperCOOL family of cryogenic probes provides a convenient and cost-effective way to significantly enhance your NMR system's sensitivity. With SuperCOOL, the probe’s detection coils and preamplifier are cooled to cryogenic temperature to reduce thermal noise to an extremely low level, resulting in a probe with a sensitivity that is two to three times higher than that of conventional room-temperature probes. This increase in sensitivity results in a four- to nine-fold reduction in experiment times - equivalent to going from a 400 MHz to a 600/700 MHz NMR system.

SuperCOOL Key Features

  • Excellent sensitivity combined with affordable purchase, running, and maintenance costs
  • Available at 400, 500, and 600 MHz
  • Compatible with all JEOL auto sample changers
  • Fully autotune-enabled using JEOL auto-tune unit
  • Variable temperature range: -40 ～ +150°C
  • Convenient & easy to use
  • Silicon (29Si) background-free

SuperCOOL Models

SuperCOOL Cooling Systems

SuperCOOL probes are available with two different cooling systems. The ideal choice for your lab will depend on the overall balance of cost, convenience, and performance.

Circulating (Closed) Cooling System

The SuperCOOL circulating cooling system is a closed-cycle system that uses cooled helium gas to cool the critical probe and preamp components to less than 70 K. This results in a probe sensitivity that is around three times higher than the equivalent room temperature probe. The gas recirculating system ensures that running costs are relatively low and there is no need to replenish the coolant during routine operation. *1 Note: only 3rd generation SuperCOOL probe is currently available with circulating cooling system.

*1: Only during continuous operation. After stoppage, replenishment of coolant will be required.

400 MHz SuperCOOL probe circulating cooling system
Example Lab Layout with SuperCOOL Circulating (Closed) System

Open-Type Cooling System

The SuperCOOL probe open-type system cools the critical electrical components to less than 85 K using liquid nitrogen from a dewar bottle, resulting in a probe with a sensitivity that is around twice that of the equivalent room temperature probe. Unlike with the circulating cooling system, the open-type system requires regular replenishment of the nitrogen coolant (refill interval typically 10 days, depending on the dewar size). Refilling of the system's nitrogen dewar can be done even while the system is running measurements, for uninterrupted, continuous use.
Furthermore, the liquid nitrogen-based cooling system results in minimal running costs.
SuperCOOL Open
400 MHz SuperCOOL probe open-type system
Example Lab Layout with SuperCOOL Open-Type System

Comparison of SuperCOOL Sensitivity with ROYALPROBE™

ROYALPROBE™
SuperCOOL probe

29Si Background-Free

JEOL cryogenic probes significantly reduce the 29Si background signals generated by probe components, enabling exceptionally clean measurements—even for glass materials. As shown in the spectra below, removing the sample tube results in a dramatic reduction of background signal, confirming that the majority of the 29Si interference originates from the tube itself rather than the probe.

With sample tube
Without sample tube

SuperCOOL MARVEL probe

SuperCOOL MARVEL is the latest generation of JEOL's liquid nitrogen cooled cryogenic probes and is the culmination of many years of our research and development in cryogenic cooling probe technology. It features a completely redesigned and optimized electrical circuit to achieve high sensitivity across a wide range of observation nuclides including 1H, 13C, 19F and 31P. The broadband design combines class-leading sensitivity across a wide range of nuclides with superior high-band performance, for an outstandingly powerful and versatile probe for both routine and advanced NMR applications, in a cost-effective and easy-to-use system.

Key Features

  • Best-in-class sensitivity: 35% improvement (avg.) over previous (third) generation SuperCOOL probe
  • Closes performance gap between nitrogen-cooled and more costly helium-cooled cryogenic probes
  • Broadband optimized probe with superior high-band ( 1H, 19F) sensitivity
  • Compatible with ECZ and ECZ Luminous™ series spectrometers

Benefits

  • Offers an outstanding price-performance ratio
  • Get your data faster - in a quarter of the time or less than using an equivalent RT probe
  • Higher throughput, greater efficiency
  • Superior versatility: one probe, many applications
  • N2 cooled for minimal running and maintenance costs

Applications

  • Pharmaceutical and chemical analyses
  • High-throughput measurements
  • Low concentration samples
  • Impurity and trace material analyses
  • Fast degrading, unstable samples
  • Advanced NMR methods

Technical Specifications

  • 5 mm broadband probe
  • Available at 400, 500 MHz and 600 MHz
  • HF tuning range : 1H, 19F
  • LF tuning range: 31P-15N (excluding 199Hg-9Be)
  • Variable temperature range：-40～＋150 °C
  • Actively shielded Z-axis gradient coil

Example Spectra

13C NMR Spectra of Estradiol (MW 272.4)

The spectra below illustrate the excellent 13C sensitivity of SuperCOOL MARVEL. A series of 13C spectra of estradiol was collected at several different analyte concentrations. For quantities of material typically used to collect 13C spectra (~20 mg), SuperCOOL MARVEL can often obtain a high SNR 13C spectrum in under one minute. Even for sample amounts in the low mg range, SuperCOOL MARVEL can obtain a 13C spectrum in a few minutes, making it ideal for routine and high-throughput applications where sample amounts are limited.

323 µg/mL Estradiol in DMSO-d6 (3 mm NMR tube)
For sub-mM sample concentrations, the outstanding high-frequency sensitivity of SuperCOOL MARVEL can allow the collection of high-quality 1D and 2D spectra without the need for very long experiment times.

500 MHz 1H NMR spectrum, 1 scan.

500 MHz 1H-13C DEPT-edited gradient HSQC, 32 scans per t1 increment, non-uniform sampling density 25%, reconstructed to 192 t1 increments.
90 minute experiment time

1 mg/mL Kanamycin Disulfate (MW 680.7)

500 MHz DEPT-edited HSQC spectrum. 4 scans per t1 increment, 128 t1 increments. Presaturation of the HOD signal was performed during the relaxation delay.
33 minute experiment time

12 mg Gramicidin S (MW 1141) in DMSO-d6

500 MHz 1H-15N sensitivity-enhanced HSQC spectrum. 2 scans per t1 increment, 42 t1 increments. 6 minute experiment time.

SuperCOOL MARVEL HFX Duo probe

Combining the class-leading sensitivity of SuperCOOL MARVEL with the HFX capabilities of ROYALPROBE™ HFX, SuperCOOL MARVEL HFX Duo is a nitrogen-cooled cryogenic probe that delivers exceptional performance for both routine and advanced NMR applications. As the only nitrogen-cooled HFX cryogenic liquids probe commercially available, it is particularly suited to labs that require a cost-effective and high-sensitivity solution for structural elucidation of fluorinated compounds by NMR.

Key Features

  • Best-in-class sensitivity: 35% improvement (avg.) over previous generation SuperCOOL probe
  • Closes performance gap between nitrogen-cooled and more expensive/complex helium-cooled cryogenic probes
  • Automatic switching between single-tune (H/F) and double-tune (H&F) modes on HF channel

Benefits

  • Excellent price-to-performance ratio
  • Significantly lower running costs than a helium cryogenic probe
  • Triple-resonance HFX experiments on a standard two-channel ECZ or ECZ Luminous™ spectrometer advanced capabilities in a more compact, lower-cost system
  • Fast, efficient analysis of fluorinated compounds
  • Greatly reduced measurement times - typically less than a quarter the time taken on an equivalent RT probe

Applications

  • Pharmaceutical and chemical analyses
  • High-throughput measurements
  • Low concentration samples
  • Impurity and trace material analyses
  • Fast degrading, unstable samples
  • Advanced NMR methods

Technical Specifications

  • 5 mm broadband probe
  • Available at 500 MHz (600 MHz coming soon)
  • HF tuning: 1H / 19F (single-tune), or 1H & 19F (double-tune)
  • LF tuning range: 31P- 15N (excluding 199Hg- 9Be)
  • Variable temperature range：-40～＋150 °C
  • Actively shielded Z-axis gradient coil

Example Spectra: Fluticasone Propionate in DMSO-d6

Below is a series of 13C spectra of fluticasone propionate collected with and without 1H and/or 19F decoupling. Used in conjunction with JEOL's ECZ or ECZ Luminous spectrometers, SuperCOOL MARVEL HFX Duo can perform triple-resonance HFX experiments, even with a standard two-channel system.

In the example shown, the use of simultaneous 1H and 19F decoupling simplifies the 13C spectrum by removing peak splittings and increases peak amplitudes, allowing the spectrum to be collected in significantly less time.

500 MHz 13C NMR spectra of fluticasone propionate collected with and without 1H and/or 19F decoupling.

Below is a standard 1H-13C multiplicity-edited HSQC spectrum of fluticasone propionate. The boxed region shows splittings in F1 due to one-bond scalar couplings between 13C and 19F

Standard 500 MHz 1H-13C edited HSQC spectrum of fluticasone propionate.

By adding a 19F broadband inversion pulse (BIP) at the middle of the t1 evolution period, these splittings are removed, simplifying the spectrum.

500 MHz 1H-13C edited HSQC spectrum of fluticasone propionate with an additional 19F BIP pulse at the mid-point of the t1 period.

SuperCOOL Probe Accessories

Probe Lifter

JEOL cryogenically cooled NMR probes are designed for maximum flexibility and uptime. Unlike conventional cryogenic probes that require lengthy warm-up cycles before removal or replacement—resulting in hours of downtime and unnecessary thermal stress—JEOL cryogenic probes can be removed from the magnet while still cold. This unique capability enables rapid switching between cryogenically cooled liquid-state probes, room-temperature liquids probes, and solid-state NMR probes, allowing laboratories to adapt quickly to changing experimental needs. Paired with the JEOL Probe Lifter, probe exchange becomes fast, safe, and effortless, helping researchers maximize instrument productivity and operational efficiency.
Probe Lifter
Probe Lifter

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