CRYO ARM™ 300 II is a cryo-electron microscope that specializes in the observation of electron beam-sensitive specimens, such as protein, for single particle analysis, tomography and MicroED. This system offers improved stability, throughput and ease of use compared to the previous generation of cryo-EMs. Moreover, this is an all-in-one system that can handle everything from screening to data acquisition, allowing for more flexibility in operation at the customer sites to meet the needs of the facility. These improvements allow users to obtain high quality images by simple operations even for those who have never used an electron microscope before.

GroEL structure at 1.98 Å resolution achieved by only 504 micrographs, a dramatic improvement from 3.1 Å resolution from 1,883 micrographs in a previous study. (as of Oct. 26, 2020 at EMDB)

Data courtesy of Dr. Junso Fujita at Osaka University

Cryo-electron micrograph (left), 3D density map (center) and fitted atomic model (right) of human hemoglobin obtained by high speed data collection, 850 movies per hour.

Specimen courtesy of Dr. Miki Kinoshita at Osaka University

2.5 Å resolution maps of the photosystem I trimer from Acaryochloris marina viewed from the stromal side perpendicular to the membrane plane (left) and from the side of the membrane plane (right).

Data courtesy of Dr. Koji Yonekura at RIKEN, Spring-8 Center

Electron diffraction pattern of a thin catalase crystal acquired with Omega filter showing clear diffraction spots visible to ~2.1 Å along the diagonal axis.

Data courtesy of Dr. Koji Yonekura at RIKEN, Spring-8 Center

Cryo-electron tomogram of isolated exosomes with a hole-free phase plate. The tomogram was obtained from micrographs of -60° to +60° tilt range at 2° steps.

Specimen courtesy of Dr. Naoomi Tominaga at National Cancer Center Research Institute and The University of Tokyo.