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A new level of flexibility for NMR analysis of fluorinated compounds prevalent in many new pharmaceutical products. 

The ROYAL HFX is the world's first liquid NMR probe with the capability to switch between single tune and dual tune modes on the high frequency coil without compromising performance. The probe can be used with routine 2-channel spectrometers or with a 3-channel system for expanded capabilities.

Operating in single tune mode, the ROYAL HFX probe has the same high performance for sensitivity and pulse widths as the current standard JEOL ROYAL NMR probe. Operating the HFX probe in dual tune mode allows for a wide variety of advanced 1H and 19F NMR experiments including 1H{19F}, 19F{1H}, X{1H,19F}, and many unique X{1H, 19F} correlation experiments to simplify spectral assignments of modern complex fluorine containing compounds for the pharmaceutical and polymer industries. The Low Frequency coil is not limited to 13C, but can be tuned to any nucleus between 31P and 15N with the same experimental flexibility as 13C experiments; a feature unique to the Royal HFX NMR Probe.

Single Tune

Dual Tune

Fluticasone Propionate

New Applications Note: Structure Elucidation of Fluorinated Compounds by NMR (New HFX NMR Probe)

JEOL ROYAL HFX Probe Application Note