AccuTOF™ LC-plus 4G Time-of-Flight Mass Spectrometer

The JMS-T100LP AccuTOF™ LC-plus 4G Time-of-Flight Mass Spectrometer is based on our award-winning AccuTOF time-of-flight analyzer platform. The AccuTOF analyzer design employs elegant ion optics and an ADC-based digitizer to deliver a dynamic range exceeding 4 orders of magnitude, without compromising sensitivity, resolution or mass accuracy.

The basic system comes standard with an orthogonal spray ESI source. Optionally available ion sources include: APCI, Dual Spray ESI, Micro ESI, Nano ESI, and the revolutionary Direct Analysis in Real Time (DART). All sources are coupled to the AccuTOF via our unique atmospheric pressure interface.

An integrated chassis consolidates all requisite spectrometer components, including pumps, into a compact benchtop footprint. This design not only saves space, but also ensures that temperature-sensitive components such as the flight tube remain under controlled conditions.

From ion source to detector, the robust AccuTOF LC-plus 4G design makes high-resolution, high-sensitivity accurate mass analyses routine.


The AccuTOF LC-plus 4G is also a simple and robust LC/MS system. It offers a wide variety of applications for LC/MS with optional Atmospheric Pressure Chemical Ionization (APCI) source, in addition to the standard orthogonal ESI source. Accurate mass measurements in LC/MS can be made routine by automating the introduction of the internal mass reference compound with the optional Auto-Injection Valve.


ColdSpray ion source

With the optional ColdSpray ion source, thermally labile analytes, including self-assembling supra molecules, some classes of organometallic complexes, short-chain double stranded DNAs, can all be analyzed intact. ColdSpray ionization was developed by Prof. Kentaro Yamaguchi, et al., of Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University (previously Chiba University) and the result of a project funded by the Japan Science and Technology Agency.

ColdSpray diagramAccuTOF LC-plus Cold Spray Diagram

Further Information

the AccuTOF LC-plus 4G brochure

AccuTOF™ LC-plus Details

  • High resolution, accurate mass spectra
  • Mass measurement of compounds with high molecular weight, i.e. peptides and proteins
  • Wide dynamic range for quantitative and qualitative analyses
  • Easy to use - simple to maintain
  • Orthogonal spray ESI source (std.), APCI, Dual Spray ESI, Micro ESI, Nano ESI, and DART (opt.)
  • Unique atmospheric pressure interface
Analysis of Acrylamide in Food by LC/Time-of-Flight Mass Spectrometry
5/16/2007 72.7 KB
Analysis of Drugs of Abuse by AccuTOF™ Dual ESI LC/TOF Mass Spectrometry
8/10/2004 125.5 KB
Analysis of Tea by Using HPLC /Time-of-Flight Mass Spectrometry
1/16/2003 202.8 KB
Automated Exact Mass Measurements and Elemental Composition Determinations
6/28/2002 158.7 KB
Convert AccuTOF™ LC into Nano-LC/MS System: An Application of Peptide Analysis
10/27/2005 43.6 KB
Determination of Haloacetic Acids in Water by LC/MS
5/26/2004 258.3 KB
Determination of Phenylalanine Isotope Ratio Enrichment by LC/Time-of-Flight Mass Spectrometry
1/13/2006 273.0 KB
Development of Coldspray Ionization Mass Spectrometry (CSI-MS) and Its Application to Labile Organometallic Compounds in Solution
6/28/2002 121.6 KB
Identification of LSD by AccuTOF™ LC/Time-of-Flight Mass Spectrometry
8/6/2004 157.2 KB
Identification of Replication Protein by Nanoelectrospray Time-of-Flight Mass Spectrometry
10/27/2003 240.8 KB
Introduction of Dual ESI and Corona ESI Ion Sources
10/24/2002 252.6 KB
LC/MS: Identification of Unknowns by Combining Exact Mass Measurement with the NIST 02 Mass Spectral Database Similarity Search
1/2/2003 225.3 KB
New Generation LC-TOF/MS "AccuTOF™"
1/2/2003 1.5 MB
Sudan Dyes Analysis by AccuTOF™ LC/MS System
2/15/2006 50.0 KB
The AccuTOF™ Orthogonal API Ion Source: Stability when Phosphate Buffer is Used
10/24/2002 274.1 KB
Using a Positive-Ion Calibration for an Exact Mass Measurement in Negative-Ion Mode
5/16/2002 130.0 KB

Pittcon Editors' Award

AccuTOF wins Pittcon 2002 Bronze
AccuTOF™ wins Pittcon® 2002 Editors' Bronze Award