14th Multidimensional Chromatography Workshop in Liege, Belgium
Earlier this month, JEOL Mass Spectrometry Product Manager Yoshi Ueda traveled to Liege Belgium to present at the 14th Multidimensional Chromatography Workshop (MDC)
. Originally started by Professor Eric Reiner of the Ministry of Environment and Climate Change (MOECC) in Toronto, this workshop returned as an in-person event for the first time since the start of the COVID-19 pandemic. Experts in multidimensional mass spectrometry from around the globe traveled to share research in Belgium’s second-largest province.
Among the focus groups, technical posters, and keynote speakers, Mr. Ueda shared with local scientists about our newly redesigned high-resolution time-of-flight mass spectrometer for GCxGC-HRMS analysis, the AccuTOF GC-Alpha
Time-of-Flight Mass Spectrometry – Now in High Resolution
JEOL’s new HRMS features increased resolving power (R > 30,000) and high mass accuracy (< 1 ppm) while also offering a variety of ionization techniques that include electron ionization (EI) as standard with the system as well as three optional soft Ionization methods – chemical ionization (CI), photoionization (PI), and field ionization (FI).
Additionally, there are 2 combination ion sources (EI/FI/FD and EI/PI) that allow for switching between hard and soft ionization without breaking vacuum. Several applications were presented to highlight the capabilities of this new-high performance HRMS when combined with comprehensive two-dimensional gas chromatography.
Exploring the Ear Canal with GC x GC-MS
One surprising application highlighted at this conference was GC x GC analysis of cerumen
otherwise known as earwax. Although co-presence of many non-volatile and/or co-eluting compounds makes analysis difficult through GC-MS or LC-MS due to the need to saponify the sample, two dimensional gas chromatography-mass spectrometry has proven a successful method for characterizing chemical components present through non-polar (primary) and mid-polar (secondary) columns without saponification.
Cannabis Analysis: A Statistical Comparison of 2 Different Strains
Another application area highlighted at the conference involved using headspace (HS) GCxGC-HRMS to statistically compare the volatiles observed for 2 cannabis strains. Additionally, SpectralWorks AnalyzerPro XD software was used to compare the data sets as it has easy setup for automatic data analysis that includes:
- Data alignment of all GCxGC data
- Peak deconvolution
- Library search
- PCA analysis
The headspace results showed the clear presence of monoterpenes, sesquiterpenes, oxygen containing monoterpenes and oxygen-containing sesquiterpenes in both samples. Additionally, there were several terpenes that were unique to each cannabis strain.
Finding the Right Fit for Your Lab
JEOL’s AccuTOF GC-Alpha is our cutting-edge HRMS instrument. To learn more about its capabilities, check out this on-demand webinar
introducing the system.
If you’re still not sure about what the best GC-MS system for your lab would be, check out this webinar
to learn more about what information is provided by which hardware and software configurations and determine the best gas chromatography-mass spectrometry system suited to your analytical application.