Rapid Confirmation of Synthetic Compounds Using DART™ –Direct Mass Spectrometric Analysis from NMR Sample Tubes
MSTips No. 223
The DART™ (Direct Analysis in Real Time) ion source was conceived at JEOL USA, Inc. in 2003 as a pioneer of the “ambient ionization” that ionizes a sample under atmospheric pressure and performs direct mass spectrometric analysis. After various developments and improvements, it was launched in the market in 2005. Today, many applications using the DART™ ion source have been published, and the number of related papers exceeds 400.
Since the DART™ ion source enables analysis in an open air under atmospheric pressure, it can handle a wide range of samples such as solids, liquids, and gases. In addition, since the measurement is only to hold the sample over the gas flow expelled from the DART™ ion source, anyone can easily and quickly perform the measurement. Many applications have been published that utilize these characteristics of DART to quickly determine the elemental composition of organic compounds. This time, we report an application related to synthetic compound confirmation that combines nuclear magnetic resonance(NMR), which is indispensable for structural analysis of organic compounds, and mass spectrometry by DART.