The occupied/emptied sites analysis of Lithium Titanium Oxide anodes: How can we obtain high resolution solid state Lithium NMR spectra? _NM200001E Lithium ion secondary batteries using spinel-type lithium titanium oxide (LTO) as the negative electrode material are excellent in safety and cycle characteristics due to their chemical stability, and have already been put into practical use. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
Visualization of hydrogen-bonding: Electron and NMR nano-crystallography_NM190004 Here, we combine ED and solid-state NMR through the first principle quantum computation with the NMR crystallography approach for crystalline structure solution. The method, electron and NMR nano-crystallography, can be applied to nano- to micro-crystals even for mixture samples. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
Spectral Separation of mixtures by solid state NMR_NM180015E Solid state NMR is a powerful tool to obtain information in the crystalline state which would be lost in the solution state. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
A 1H Solid State NMR Application for Pharmaceutical Development by using Ultra Fast MAS: Drug-Polymer Intermolecular Interaction on Solid Dispersions_NM190003E The low oral bioavailability of a drug due to its poor aqueous solubility is a major challenge for pharmaceutical development. Solid dispersion (SD), where the amorphous drug is dispersed into the polymer matrix, is one of the useful approaches to improve the aqueous solubility. However, thermodynamically unstable nature of an amorphous drug increases its susceptibility to recrystallize upon storage, which, in turn, reduces its solubility and dissolution. Therefore, design of thermodynamically stable SD is required. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
Overtone solid-state NMR spectroscopy on Nitrogen-14_NM180002E 15N NMR is widely used because of the importance of nitrogen in chemistry, materials, biology, environment, etc. However, very low abundance of 15N (<0.4%) results in poor sensitivity and thus makes observation time-consuming. On the other hand, the rest of nitrogen atoms are also NMR sensitive nucleus of 14N. Despite the high abundance of 14N (>99%), it's application is rather limited due to the huge quadrupolar interactions and its spin quantum number I = 1. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
AUTOMAS: Efficient time management in solid state NMR_NM180003E JEOL AUTOMAS probe combined with Auto Sample Changer and Auto Tune Unit allows for fully automated solid NMR measurements including sample load/eject, tuning and matching, magic angle spinning frequency control, and temperature control. This enables you to manage efficient data collection as liquid NMR. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
2.5 / 3.2 / 4.0 mm XY-MAS probe We can supply 2.5, 3.2 or 4.0 mm XY-MAS probes suitable for inorganic materials. The XY-MAS probe has two rf channels which enable simultaneous strong rf-field irradiation. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
X-ray, Electron and NMR Crystallography to Structural Determination of Small Organic Molecules Here we present the recent development at RIKEN CLST-JEOL collaboration laboratory to explore the molecular structures of low-molecular weight pharmaceutical compounds in natural abundance (without any isotopic labeling); the recent progress in fast magic angle spinning (MAS) technology in solid-state nuclear magnetic resonance (ssNMR) and in ultra high sensitivity camera in transmission electron microscopy (TEM) paves a new way to answer problems in the pharmaceutical industry and sciences. 1) Crystalline polymorphs and 2) salt/cocrystal are two major concerns in terms of quality control, stability, and intellectual property. To identify the crystalline form, powder X-ray diffraction and 13C cross-polarization MAS ssNMR are widely used methods, however, the former is sometimes not suitable for mixture analysis and latter fails to distinguish crystalline forms with similar molecular conformations. To solve these issues, we use electron diffraction (ED) and 1H fast MAS NMR. The crystalline form can be determined from nano- to micro-meter sized single crystals using ED, since electron interactions are 4 to 5 order stronger than X-ray interactions. 1H NMR also gives suitable information to molecular packing since 1H is located at the surface of the crystals. The salt/cocrystal issue, where hydrogen plays a key role, is a serious problem, since single crystal X-ray diffraction (SCXRD) cannot determine the hydrogen atom position precisely. Here we determine the internuclear distances between 1H and 15N using ssNMR at fast MAS conditions, while the global structure is obtained through SCXRD, answering the salt/cocrystal questions. March 7, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>