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Analytical Instrument Documents

The ROYALPROBE™ HFX can simultaneously irradiate 1H, 19F, and 13C (or other X-nuclei) even in a basic console with basic two-channel console, and is a versatile probe that can measure a wide-variety of nuclei at high sensitivity. Here we introduce some useful experiments for fluorine-containing compounds that can be run on conjunction with JNM-ECZ400S equipped with ROYALPROBE™ HFX.

Fluorine and nitrogen containing organic compounds are often found in a variety of fields such as pharmaceutical and material sciences. Such compounds show unique properties based on their conformations and orientations, which are often induced by hydrogen bonds between N-H and F atoms. Therefore, analysis of molecular conformations and inter-molecular interactions are important. Here, we report 14N decoupled 1H-19F HETCOR as an example of hydrogen bonds analysis between N-H and F for fluorinated benzanilide as a demonstration.

Fluorine is increasingly being used in many new drugs. Fluorine is now appearing in illicit and illegal synthetic drugs. Fluoro Polymers are important to everyday life, for example PTFE (Teflon™).

NMR Probe for Fluorine NMR. What is needed is a Robust Routine HFX NMR Probe that can do every routine experiment well! Including all HFX experiments, 1H{19F}, 19F{1H}, 13C{1H,19F} & X{1H,19F}.

The JEOL ROYAL HFX NMR probe is the world’s first liquid NMR probe switchable between single tune and dual tune mode on the High Frequency coil without compromising the NMR performance. The ROYAL HFX probe operating in single tune mode has the same sensitivity and pulse width performance as the standard ROYAL NMR probe.

Fluorine is found with an ever-increasing frequency in materials science and both legal and illicit drugs [ref 1-5]. In this application note results are presented to illustrate the simplification afforded by the routine application of triple-resonance NMR to clearly assign voriconazole, a molecule containing proton, carbon, and nitrogen molecules with many atoms exhibiting J-coupling to fluorine. The HFX ROYAL probe is a completely new probe technology utilizing magnetic coupling to afford highly efficient HF-X tuning which can function as a simple switch to highest sensitivity dedicated 1H or 19F or very well balanced dual 1H/19F performance on demand. References 6-8 detail the technological developments for the HFX ROYAL probe.

Fluorine and nitrogen containing organic compounds are often found in a variety of fields such as pharmaceutical and material sciences. Such compounds show unique properties based on their conformations and orientations, which are often induced by hydrogen bonds between N-H and F atoms. Therefore, analysis of molecular conformations and inter-molecular interactions are important. Here, we report 14N decoupled 1H–19F HOESY (hetero nuclear NOE) for fluroinated benzanilide (1) as a demonstration.

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Other Resources

Image Gallery
  • View a selection of NMR and MS spectra
  • Walkup NMR
  • See how the Delta NMR software allows users to just "walk up" and start NMR experiments
  • Mass Spec Reference Data
  • View our page of useful molecular references for Mass Spec
  • Tutorials (Mass Spec)
  • Documents on the basics of mass spectrometry
  • Delta NMR software Tutorials
  • Videos on how to use the Delta NMR software
  • No-D NMR
  • Description of No-D NMR and how it can be used to eliminate the need for deuterated solvents
  • Non Uniform Sampling (NUS)
  • Description of how NUS is used to greatly reduce the time needed for running NMR experiments
  • NMR Basics
  • Overview of the Basics of NMR Theory
  • NMR Magnet Destruction
  • See our presentation of the slicing open of a JEOL Delta-GSX 270 MHz NMR Magnet
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    Corona - Glow Discharge (DART Ion Source)

    January 28, 2022
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