14N decoupled HETCOR for 19F-mediated amide hydrogen bonds with ROYALPROBE™ HFX_NM190011E Fluorine and nitrogen containing organic compounds are often found in a variety of fields such as pharmaceutical and material sciences. Such compounds show unique properties based on their conformations and orientations, which are often induced by hydrogen bonds between N-H and F atoms. Therefore, analysis of molecular conformations and inter-molecular interactions are important. Here, we report 14N decoupled 1H-19F HETCOR as an example of hydrogen bonds analysis between N-H and F for fluorinated benzanilide as a demonstration. July 28, 2020 Nuclear Magnetic Resonance (NMR), ROYALPROBE HFX 0 Comment Read More >>
Structure Elucidation of Fluorinated Compounds by NMR Fluorine is increasingly being used in many new drugs. Fluorine is now appearing in illicit and illegal synthetic drugs. Fluoro Polymers are important to everyday life, for example PTFE (Teflon™). March 6, 2020 Nuclear Magnetic Resonance (NMR), ROYALPROBE HFX 0 Comment Read More >>
JEOL ROYAL HFX NMR Probe Overview NMR Probe for Fluorine NMR. What is needed is a Robust Routine HFX NMR Probe that can do every routine experiment well! Including all HFX experiments, 1H{19F}, 19F{1H}, 13C{1H,19F} & X{1H,19F}. March 6, 2020 Nuclear Magnetic Resonance (NMR), ROYALPROBE HFX 0 Comment Read More >>
JEOL ROYAL HFX NMR Probe - A New NMR Probe for 1H, 19F & X NMR Experiments The JEOL ROYAL HFX NMR probe is the world’s first liquid NMR probe switchable between single tune and dual tune mode on the High Frequency coil without compromising the NMR performance. The ROYAL HFX probe operating in single tune mode has the same sensitivity and pulse width performance as the standard ROYAL NMR probe. March 6, 2020 Nuclear Magnetic Resonance (NMR), ROYALPROBE HFX 0 Comment Read More >>
Application of HFX NMR to Facilitate the Complete Assignment of the Anti-fungal Agent Voriconazole Fluorine is found with an ever-increasing frequency in materials science and both legal and illicit drugs [ref 1-5]. In this application note results are presented to illustrate the simplification afforded by the routine application of triple-resonance NMR to clearly assign voriconazole, a molecule containing proton, carbon, and nitrogen molecules with many atoms exhibiting J-coupling to fluorine. The HFX ROYAL probe is a completely new probe technology utilizing magnetic coupling to afford highly efficient HF-X tuning which can function as a simple switch to highest sensitivity dedicated 1H or 19F or very well balanced dual 1H/19F performance on demand. References 6-8 detail the technological developments for the HFX ROYAL probe. March 6, 2020 Nuclear Magnetic Resonance (NMR), ROYALPROBE HFX 0 Comment Read More >>
14N decoupled 1H–19F HOESY with ROYALPROBE™ HFX_NM190012E Fluorine and nitrogen containing organic compounds are often found in a variety of fields such as pharmaceutical and material sciences. Such compounds show unique properties based on their conformations and orientations, which are often induced by hydrogen bonds between N-H and F atoms. Therefore, analysis of molecular conformations and inter-molecular interactions are important. Here, we report 14N decoupled 1H–19F HOESY (hetero nuclear NOE) for fluroinated benzanilide (1) as a demonstration. February 10, 2020 Nuclear Magnetic Resonance (NMR), ROYALPROBE HFX HOESY 0 Comment Read More >>