JEOL ROYAL HFX NMR Probe - A New NMR Probe for 1H, 19F & X NMR Experiments March 6, 2020 Nuclear Magnetic Resonance (NMR), ROYALPROBE HFX 0 The JEOL ROYAL HFX NMR probe is the world’s first liquid NMR probe switchable between single tune and dual tune mode on the High Frequency coil without compromising the NMR performance. The ROYAL HFX probe operating in single tune mode has the same sensitivity and pulse width performance as the standard ROYAL NMR probe. APPLICATION EXAMPLES OF ROYAL HFX PROBE Operating the HFX probe in dual tune mode allows for a wide variety 1H and 19F of advanced NMR experiments including 1H{19F}, 19F{1H}, 13C{1H,19F}, and many unique 13C{1H, 19F} correlation experiments to simplify spectral assignments of modern complex fluorine containing compounds for the pharmaceutical and polymer industries. For full details: Attached files often contain the full content of the item you are viewing. Be sure and view any attachments. JEOL ROYAL HFX Probe.pdf 1.84 MB Related Articles JEOL ROYAL HFX NMR Probe Overview NMR Probe for Fluorine NMR. What is needed is a Robust Routine HFX NMR Probe that can do every routine experiment well! Including all HFX experiments, 1H{19F}, 19F{1H}, 13C{1H,19F} & X{1H,19F}. Cryogenic probes: the development of “UltraCOOL” & “SuperCOOL” probes In 2013, JEOL RESONANCE launched the cryogenic NMR probe systems,”UltraCOOL” and “SuperCOOL”. Delivering sensitivity far exceeding conventional room temperature probes together with ease of use beyond that previously associated with cooled probes, such as probe change whilst cooled, and variable temperature measurement capability, the products received a lot of positive response. However, many dramatic stories lay behind the birth of these products. 14N decoupled 1H–19F HOESY with ROYALPROBE™ HFX_NM190012E Fluorine and nitrogen containing organic compounds are often found in a variety of fields such as pharmaceutical and material sciences. Such compounds show unique properties based on their conformations and orientations, which are often induced by hydrogen bonds between N-H and F atoms. Therefore, analysis of molecular conformations and inter-molecular interactions are important. Here, we report 14N decoupled 1H–19F HOESY (hetero nuclear NOE) for fluroinated benzanilide (1) as a demonstration. 14N decoupled HETCOR for 19F-mediated amide hydrogen bonds with ROYALPROBE™ HFX_NM190011E Fluorine and nitrogen containing organic compounds are often found in a variety of fields such as pharmaceutical and material sciences. Such compounds show unique properties based on their conformations and orientations, which are often induced by hydrogen bonds between N-H and F atoms. Therefore, analysis of molecular conformations and inter-molecular interactions are important. Here, we report 14N decoupled 1H-19F HETCOR as an example of hydrogen bonds analysis between N-H and F for fluorinated benzanilide as a demonstration. SuperCOOL Probe In comparison with the UltraCOOL probe, SuperCOOL probe represents a cryogenic probe with high sensitivity at lower cost and power consumption. Thermal noise reduction due to new designed cooling system greatly enhances the sensitivity of NMR measurement. Non Uniform Sampling in Routine 2D Correlation Experiments Data obtained from two-dimensional NMR experiments is incredibly useful for structure elucidation of complex molecules, especially when their one-dimensional spectra feature overlapping peaks. However, some experiments require significant amounts of time in order to yield data with adequate resolution or signal to noise for unambiguous interpretation. Any means of reducing the total acquisition time is useful. In this Note, we’ll explore a technique known as Non Uniform Sampling (NUS), demonstrate how it can be used to speed up data collection, and highlight how it can be employed in Delta™ on JEOL Spectrometers. Showing 0 Comment Comments are closed.