Structure Elucidation of Fluorinated Compounds by NMR March 6, 2020 Nuclear Magnetic Resonance (NMR), ROYALPROBE HFX 0 Introduction Fluorine is increasingly being used in many new drugs As of 2011 there were approximately 200 fluorine containing drugs. [ref 1] Fluoro-organic compounds account for 40% of the new chemical entities entering phase III trials in 2012 and 2013. [ref 2] Fluorine is use in a wide range of drug applications including: Anesthetics, Antacids, Anti-anxiety, Antibiotics, Antidepressants, Anti-fungal antibiotics, Antihistamines, Antilipemics, Anti-malarial, Antimetabolites, Appetite suppressants, Arthritis/anti-inflammatory agents, Psychotropic, Steroids/anti-inflammatory agents. [ref 3] Fluorine is now appearing in illicit and illegal synthetic drugs: These include: Cannabinoids [ref 4], and psychedelic phenethylamines [ref 5] Fluoro Polymers are important to everyday life, for example PTFE (Teflon™) Challenges The potential Fluorine chemical shift range is 500 ppm, 188 kHz at 9.4T (1H 400 MHz) to 282 kHz at 14.1T (1H 600 MHz). 19F-1H j coupling constants up to 60 Hz 19F-13C j coupling constants up to 280 Hz 19F long range J coupling interactions complicate NMR spectra making interpretation difficult These spectral features combine to make 19F difficult to excite and to decouple from other nuclei. For full details: Attached files often contain the full content of the item you are viewing. Be sure and view any attachments. JEOL Structure Elucidation of Fluorinated Compounds by NMR.pdf 1.58 MB Showing 0 Comment Comments are closed.