Residual solvent analysis in cosmetic ingredient using single QMS mode and alternative carrier gases in GC/MS/MS
Introduction
The gas chromatograph triple quadrupole mass spectrometer JMS-TQ4000GC UltraQuad™ TQ (Fig. 1) can be used as QMS by single QMS mode in addition to qualitative and quantitative analysis of trace components by MS/MS mode. We have already reported quantitative analysis in water samples and qualitative analysis in material samples in MSTips No. 443 and 450. In this time, we report the analysis of residual solvents in cosmetic ingredient using the single QMS mode. Residual solvents in cosmetic ingredient, like residual solvents in pharmaceuticals, are classified as Class 1-3 solvents by the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH). Class 1 solvents: Solvents to be avoided in the manufacture of pharmaceuticals. Class 2 solvents: Solvents to be limited in pharmaceuticals. Class 3 solvents: Solvents with low toxic potential[1]. In this application note, we report the analysis of residual solvents in ethanol solution using nitrogen gas as an alternative carrier gas for seven solvent components classified as Class 1 and 2, as well as the quantitative analysis of 1,4-Dioxane in cosmetic ingredient.