Analysis of Drugs of Abuse by AccuTOF™ Dual ESI LC/TOF Mass Spectrometry
For identification of drugs of abuse in forensic science, the unambiguous identification of chemical substances is crucial. The new AccuTOF™ Dual ESI LC/TOF-MS system offers easy exact-mass measurements and elemental composition determinations. A robust design and stable time-of-flight mass analyzer are combined with a detection system that provides high sensitivity and high dynamic range. We used this system for analyzing the samples of drug substances containing the opiates and stimulants. The detection limit for codeine is 1.25 pg/μL. The mass accuracy is smaller than 3 ppm over a wide concentration range, from 1.25 pg/μL to 10 ng/uL.
The system included a JEOL AccuTOF™ Dual ESI timeof- flight mass spectrometry system and an Agilent 1100 HPLC. All instruments were controlled by a JEOL MassCenter™. All solvents used were of HPLC grade. The standard solutions were purchased from Alltech (Deerfield, IL) and diluted in mobile phase A with the concentrations ranging from 1.25 ng/mL to 10 μg/mL.