Instantaneous Screening for Counterfeit Drugs with No Sample Preparation March 4, 2020 2. Drug Analysis, 4. Forensics, AccuTOF™ DART®, Application Note, Mass Spectrometry (MS) 0 Drug counterfeiting is becoming a serious and widespread public health problem. The number of FDA open investigations into drug counterfeiting rose sharply from 2000 to 2001 and has remained high in recent years. Counterfeit drugs are not only illegal, but dangerous; they may contain little or no actual drug content, or they may contain completely different drugs with potentially toxic consequences. The problem is worldwide; it has been reported that nearly 50% of all anti-malarial drugs in Africa are thought to be counterfeit. Direct Analysis in Real Time (DART™) offers a simple solution to screening for counterfeit drugs. DART can detect the presence or absence of drugs in medicines within seconds by simply placing the pill or medicine in front of the mass spectrometer. In combination with the AccuTOF, DART provides exact masses and accurate isotopic patterns that provide elemental compositions for known and unknown substances. For full details: Attached files often contain the full content of the item you are viewing. Be sure and view any attachments. Drug Screening.pdf 54.75 KB Related Articles Direct Analysis of Drugs in Pills and Capsules with No Sample Preparation The AccuTOF™ equipped with Direct Analysis in Real Time (DART™) is capable of analyzing drugs in pills and capsules with no sample preparation. In most cases, the pill can simply be placed in front of the DART and the active ingredients can be detected within seconds. This application note shows a wide variety of pills that have been analyzed by using DART. The examples include prescription drugs, over-the-counter medicines, and illicit drugs that were confiscated by a law-enforcement agency. Sample tube grade affects resolution Some low-grade, inexpensive NMR sample tubes have large warpage, low wall thickness uniformity, and large distortion, which may adversely affect the resolution. The effect of low-grade sample tubes, such as disposable ones, on the resolution is small in low-field NMR, but it may be noticeable in high-field NMR. In addition, some disposable sample tubes are thicker or thinner than the nominal value and will not fit in the sample holder. Instantaneous Detection of Illicit Drugs on Currency The widespread presence of illicit drugs on currency is an indication of the extent of the worldwide substance abuse problem. Remarkably, cocaine can be found on virtually all one-dollar bills in the United States — the upper limit for the general background level of cocaine is estimated to be 13 ng per bill. The Direct Analysis in Real Time (DART™) ion source, combined with the AccuTOF™ mass spectrometer can be used to sample drugs on currency within seconds. No sample preparation (extraction, wipes, etc.) or chromatography is required. The bill is placed in front of the DART and the presence of drugs can be detected immediately. Only a small portion of the bill is sampled at any given time. This allows the analyst to view the distribution of drugs on the surface of a bill, and allows the bill to be retained for reexamination at a later time. Visualizing fragmentation channels of polyethylene oxide with different end groups using the JMS-S3000 SpiralTOFTM with TOF–TOF option Tandem mass spectrometry is a powerful tool for polymer characterization. It can obtain information about polymer end groups, repeating structures (linear, cyclic, or branched), and copolymerization. High-energy collision–induced dissociation (HE-CID) is a fragmentation method that is available only in tandem time-of-flight mass spectrometry (TOF–TOF). The informative fragmentation channels, which are difficult to observe with commonly used low-energy CID, are often observable in HE-CID spectra. In MSTips 270, we proposed a method to visualize this abundant structural information and enable intuitive analysis using the “Remainders of KM” (RKM) plot method. In this report, we applied the method to analyze polyethylene oxide (PEO) with different end groups. Analysis of Scotch Whiskey and Tequila Samples by Solid-Phase Microextraction and High-Resolution GC/MS Solid-phase microextraction (SPME) is a convenient sample preparation method for extracting organic compounds from aqueous samples. The combination of SPME with gas chromatography and high-resolution mass spectrometry provides powerful capabilities for the analysis of alcoholic beverages. Two samples of Scotch whiskey and one tequila sample were sampled by using solid-phase microextraction for analysis by high-resolution GC/MS. Sample 1 was a blended 12-year old light Scotch whiskey, while sample 2 was a 12-year old single-malt light Scotch whiskey. The tequila sample was a popular brand that is widely sold in the USA. Compounds were extracted and identified by GC/MS with library search. Exact mass measurements provided elemental compositions for molecular ions and fragment ions. MS imaging for visualizing synthetic polymers combined with KMD - MSTips - 306 In this report, we have combined this method with the Kendrick Mass Defect (KMD) method to effectively visualize polymer series mixtures. Showing 0 Comment Comments are closed.