New Generation LC-TOF/MS “AccuTOFTM” March 5, 2020 AccuTOF™ LC, Application Note, Mass Spectrometry (MS) 0 Introduction It has been a decade since Dodonov and his colleagues [1] first announced the electrospray ionization time-of-flight mass spectrometer (ESI-TOF MS). Their initial findings have been enhanced by Standing and others [2,][ 3], and it has been recently reported that a large TOF MS system achieved a mass resolution exceeding 10,000 [4]. Encouraged by the results acquired by Dodonov and Standing, some of the MS manufactures have produced bench top ESI-TOF MS systems. However, most of these commercial models have a narrow dynamic range and are unfit to quantitative analysis because they use a TDC (Time-to-Digital Converter) as a data acquisition system. Their applications were mainly in qualitative analysis with exact mass measurement, and are limited in such fields as environmental studies and chemical dynamics that require only qualitative analysis. Because of detector saturation, these systems only show good mass acuracy when operated within a limited analyte concentration range. For full details: Attached files often contain the full content of the item you are viewing. Be sure and view any attachments. AccuTOF.pdf 1.43 MB Related Articles New Generation LC-TOF/MS "AccuTOF" It has been a decade since Dodonov and his colleagues first announced the electrospray ionization time-of-flight mass spectrometer (ESI-TOF MS). Their initial findings have been enhanced by Standing and others, and it has been recently reported that a large TOF MS system achieved a mass resolution exceeding 10,000. What Is the Opposite of Pandora’s Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources The introduction of DART and DESI sources approximately seven years ago led to the development of a new series of atmospheric pressure ion sources referred to as “ambient ionization” sources. These fall into two major categories: spray techniques like DESI or plasma techniques like DART. The selectivity of “direct ionization,” meaning analysis without chromatography and with little or no sample preparation, depends on the mass spectrometer selectivity. Although high resolution and tandem mass spectrometry are valuable tools, rapid and simple sample preparation methods can improve the utility of ambient ionization methods. The concept of ambient ionization has led to the realization that there are many more ways to form ions than might be expected. An interesting example is the use of a flint-and-steel spark source to generate ions from compounds such as phenolphthalein and Gramicidin S. Introduction of latest GC/HR-TOFMS system: JMS-T200GC AccuTOF GCx - High Mass Resolution JEOL has recently announced a 4th generation GC/HR-TOFMS system, the JMS-T200GC AccuTOF GCx, in 2015. The AccuTOF-GCx offers high sensitivity, high mass resolving power, high mass accuracy, and a wide dynamic range in combination with high-speed data acquisition. In this application note, we show the high mass resolution that can be obtained with this latest GC/HR-TOFMS system. JMS-Q1500GC Gas Chromatograph Quadrupole Mass Spectrometer This new generation GC/MS system has excellent performance characteristics that represent a further advancement of our quadrupole MS technology. The JMS-Q1500GC can be used for a wide range of applications such as environmental analysis for agrichemicals and mold odor, material analysis, and aroma analysis. The AccuTOF™-DART® 4G: The Ambient Ionization Toolbox™ JEOL introduced the AccuTOF-DART in 2005 as the first commercially available ambient ionization mass spectrometer system. The atmospheric pressure ionization interface (API) for the AccuTOF system, originally designed as a simple, rugged and reliable LC/MS interface, became the ideal platform for developing the Direct Analysis in Real Time (DART) ion source. Because the DART ion source can be positioned directly in front of the AccuTOF sampling orifice without additional interface hardware, a variety of ambient ionization techniques are available to the AccuTOF-DART operator without removing the DART ion source. The third-generation AccuTOF-DART 4G system is an “ambient ionization toolbox” that allows the analyst to choose ionization methods that are best matched to the samples to be analyzed. Evolved gas monitoring from PA66 by using PY-GC-HRTOFMS Compounds which are generated upon heating polymer materials include monomers, additives and fragments characteristic of the polymer materials. Low molecular weight compounds generated by pyrolysis and/or locally desorption are observed. The relationship between the behavior of evolved gas compounds and the heating temperature is important for understanding the chemical characteristics of polymer materials. A gas chromatograph (GC) - mass spectrometer (MS) with thermogravimetric / differential thermal analyzer (TG/DTA) or pyrolyzer (Py) is generally used to identify the thermally evolved gas compounds from polymer materials. However, GC with a low-resolution MS such as quadrupole MS (QMS) may have difficulty monitoring low molecular-weight compounds generated by heating, since the GC is not used to provide chromatographic separation and QMS has poor mass spectrometric separation in the low mass region. (For example, N2+·, CO+· and C2H4+· are detected as the same signal of nominal mass m/z 28.) We report the use of Py - GC - high resolution time-of-flight MS (HRTOFMS) for monitoring the low-molecular weight compounds generated upon heating the polymer materials. This report focuses on the generation of low molecular weight compounds near m/z 18, 28, and 4. Showing 0 Comment Comments are closed.