Analytical Instrument Documents

Disclaimer: These data are for informational use only. No guarantees are made for the accuracy of the data presented.

Disclaimer: These data are for informational use only. No guarantees are made for the accuracy of the data presented.

Disclaimer: These data are for informational use only. No guarantees are made for the accuracy of the data presented.

Disclaimer: These data are for informational use only. No guarantees are made for the accuracy of the data presented.

It has been a decade since Dodonov and his colleagues first announced the electrospray ionization time-of-flight mass spectrometer (ESI-TOF MS). Their initial findings have been enhanced by Standing and others, and it has been recently reported that a large TOF MS system achieved a mass resolution exceeding 10,000.

Mass spectrometers are commonly combined with separation devices such as gas chromatographs (GC) and liquid chromatographs (LC). The GC or LC separates the components in a mixture, and the components are introduced, one by one, into the mass spectrometer. MS/MS is an analogous technique where the first-stage separation device is another mass spectrometer.

Accurate mass measurements are frequently used to determine the elemental composition for molecular and fragment ions. These measurements are normally obtained by acquiring a high resolution mass spectrum so that the masses are measured for a single species and not measured for unresolved or partially resolved peaks.

What does a mass spectrometer do? What are mass spectrometers used for? What does the mass tell us? How does a mass spectrometer work?

Several different definitions of resolution are used in mass spectrometry. It is useful to understand the distinctions between the different definitions to understand the characteristics of different mass spectrometers.

The JMS-S3000 "SpiralTOF™" is a MALDI-TOFMS that incorporates an innovative SpiralTOF ion optics system. The JMS-S3000 is available with a TOF-TOF option that can acquire high-energy collision-induced dissociation (CID) product ion spectra for monoisotopically selected precursor ions.