Cold-Spray TOFMS: Effect of Retractable Flow Redirector
MS Tips No. 035
In general LC-MS, ESI is known to be effective for analysis of ionic or polar compounds as the softest ionization method. However, it is extremely difficult for ESI to identify the structure of labile organic compounds in solution. Cold-spray ionization１） is a new technique recently developed to solve this problem. Cold-spray ionization, reported by Dr. Kentaro Yamaguchi, Tokushima Bunri University, is designed to ionize samples at low temperature by cooling nitrogen gas spray. Ions generated by this technique are likely to be ionized while maintaining the associative structure reflecting the inherent properties of molecules. Studying these ions will enable general structural analysis including molecular functions and peripheral environment. In 2003 JEOL announced the JMS-T100CS AccuTOF CS, incorporating a new ion source designed to support cold-spray ionization. The new ion source features a retractable flow redirector designed to switch the direction of spray between vertical and coaxial. We analyzed proline in an AccuTOF CS, studying the effect of the retractable flow redirector.