Study on higher sensitivity for analysis of pesticide residues in foods by using GC-MS/MS (3)
Introduction
The analysis of pesticide residues in foods requires the separation and detection of trace amounts of target pesticides present in complex matrices, and therefore, analytical instruments used for such measurements must have high performance. The GC-MS/MS method is effective for simultaneous analysis of multiple components in complex matrices, and is currently used by many analytical institutions as a general analytical method. Naturally, detection sensitivity can differ depending on the analytical instrument used, but various methods exist to increase the sensitivity of conventional analytical methods. In MSTips No. 413, an MMI was used to examine the effect of cold splitless injection on sensitivity, in contrast to conventional hot splitless injection. In MSTips No. 414, the effect of the EPIS on sensitivity was compared to a standard EI ion source. The results of each study showed a certain level of sensitivity improvement compared to the conventional method, but these methods can be applied simultaneously and further improvement in detection sensitivity can be expected due to an additive effect. In this study, the results of a comparison of the detection sensitivity enhancement effect by an analysis combining the cold splitless injection of an MMI as the GC sample injection method and the enhanced performance ion source (EPIS).