Introduction of Dual ESI and Corona ESI Ion Sources March 5, 2020 AccuTOF™ LC, Application Note, Mass Spectrometry (MS) 0 We have developed two new ion sources, the Dual ESI and Corona ESI, for the AccuTOF LC-TOF MS system that was introduced in the spring of 2002. The Dual ESI (Figure 1) provides two ESI (electrospray ionization) sprayers. This permits the introduction of a reference compound without disturbing or suppressing the spray of the analyte. In addition, the dual-probe system can be useful for high-throughput analysis. The Corona ESI ion source (Figure 2) is equipped with both an ESI sprayer and a corona-discharge electrode. The combination of ESI and APCI (atmospheric pressure chemical ionization) in a single source is useful for rapid analysis of unknown elements, and for improved efficiency in determining optimal analysis conditions. In addition, the orthogonal spray ion sources feature long-term stability and easy maintenance. For further details about the orthogonal-spray API source, refer to applications note MS-021024B. For full details: Attached files often contain the full content of the item you are viewing. Be sure and view any attachments. Dual and Corona ESI.pdf 246.64 KB Related Articles What Is the Opposite of Pandora’s Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources The introduction of DART and DESI sources approximately seven years ago led to the development of a new series of atmospheric pressure ion sources referred to as “ambient ionization” sources. These fall into two major categories: spray techniques like DESI or plasma techniques like DART. The selectivity of “direct ionization,” meaning analysis without chromatography and with little or no sample preparation, depends on the mass spectrometer selectivity. Although high resolution and tandem mass spectrometry are valuable tools, rapid and simple sample preparation methods can improve the utility of ambient ionization methods. The concept of ambient ionization has led to the realization that there are many more ways to form ions than might be expected. An interesting example is the use of a flint-and-steel spark source to generate ions from compounds such as phenolphthalein and Gramicidin S. 19F-detected dual-optimized inverted 1JCC 1,n-ADEQUATE Modification of the recently reported 19F-detected 1,1-ADEQUATE experiment that incorporates dual-optimization to selectively invert a wide range of 1JCC correlations in a 1,n-ADEQUATE experiment is reported. Parameters for the dual-optimization segment of the pulse sequence were modified to accommodate the increased size of 1JCC homonuclear coupling constants of poly- and perfluorinated molecules relative to protonated molecules to allow broadband inversion of the 1JCC correlations. The observation and utility of isotope shifts are reported for the first time for 1,1- and 1,n-ADEQUATE correlations. Simultaneous determination of residual agricultural chemicals in food by GC-MS/MS - MSTips259 As "food safety" is recognized as an increasingly important issue on a global scale, many nations have their own regulations on residual agricultural chemicals in food. In Japan, the positive list system, which was enforced at the end of May 2006, stipulates a uniform standard of 10 ppb as a quantity that is considered safe for human health. Under the positive list system, more agricultural chemicals need to be examined, and as a result, techniques capable of accurately and collectively analyzing residual agricultural chemicals in food are in increasing demand. While mass spectrometry (MS) is known for its high detection sensitivity, MS/MS is becoming the mainstream of pesticide analysis for its superior sensitivity and selectivity. The JMS-TQ4000GC, JEOL’s latest GC-MS/MS system, has a unique ion storage/ejection mechanism within the MS/MS collision cell and incorporates new firmware to support MS/MS analysis with up to 36,000 transitions. In this work, we report the verified results for pesticide residues sensitivity in food using the JMS-TQ4000GC. Stability in quantitative analysis of residual agricultural chemicals in food by GC-MS/MS - MSTips262 As "food safety" is recognized as an increasingly important issue on a global scale, many nations have their own regulations on residual agricultural chemicals in food. In Japan, the positive list system, which was enforced at the end of May 2006, stipulates a uniform standard of 10 ppb as a quantity that is considered safe for human health. Under the positive list system, more agricultural chemicals need to be examined, and as a result, techniques capable of accurately and collectively analyzing residual agricultural chemicals in food are in increasing demand. While mass spectrometry (MS) is known for its high detection sensitivity, MS/MS is becoming the mainstream of pesticide analysis for its superior sensitivity and selectivity. The JMS-TQ4000GC, JEOL’s latest GC-MS/MS, has a unique ion storage/ejection mechanism within the MS/MS collision cell and incorporates new firmware to support MS/MS analysis with up to 36,000 transitions. In this work, we report the stability of 8 pesticides that were added to spinach extract. Corona - Glow Discharge (DART Ion Source) mp4 video of Corona - Glow Discharge (DART Ion Source) Analysis of Drugs of Abuse by AccuTOF™ Dual ESI LC/TOF Mass Spectrometry For identification of drugs of abuse in forensic science, the unambiguous identification of chemical substances is crucial. The new AccuTOF™ Dual ESI LC/TOF-MS system offers easy exact-mass measurements and elemental composition determinations. A robust design and stable time-of-flight mass analyzer are combined with a detection system that provides high sensitivity and high dynamic range[1]. We used this system for analyzing the samples of drug substances containing the opiates and stimulants. The detection limit for codeine is 1.25 pg/μL. The mass accuracy is smaller than 3 ppm over a wide concentration range, from 1.25 pg/μL to 10 ng/uL. Showing 0 Comment Comments are closed.