Analytical Instrument Documents

JEOL Resources

rss

Documentation in support of your JEOL product.

MALDI for Small Molecule Analysis: A Complex Drug Mixture

Introduction

Matrix-Assisted Laser Desorption Ionization (MALDI) applications to small molecule analysis are often considered to be limited by low-mass matrix ions that can be isobaric with the target analytes. However, with sufficient resolving power, matrix ions and analyte ions can be separated. Additionally, these resolved matrix ions can serve as internal mass reference standards for exact mass measurements.

The SpiralTOF’s unique multi-turn ion optics package a very long (17-meter) flight path within a 1-meter space. Electric sectors and Matsuda plates provide perfect focusing to eliminate ion loss due to beam divergence. Post-source decay fragments occurring in the flight path are eliminated by the ion optics, providing a clean and artifact-free background.

This is shown here for the high-resolution analysis of a mixture of 32 small-molecule drugs analyzed by MALDI with the JEOL SpiralTOF mass spectrometer.

Attached Files
Showing 0 Comment


Comments are closed.

Other Resources

Image Gallery
  • View a selection of NMR and MS spectra
  • Walkup NMR
  • See how the Delta NMR software allows users to just "walk up" and start NMR experiments
  • Mass Spec Reference Data
  • View our page of useful molecular references for Mass Spec
  • Tutorials (Mass Spec)
  • Documents on the basics of mass spectrometry
  • Delta NMR software Tutorials
  • Videos on how to use the Delta NMR software
  • No-D NMR
  • Description of No-D NMR and how it can be used to eliminate the need for deuterated solvents
  • Non Uniform Sampling (NUS)
  • Description of how NUS is used to greatly reduce the time needed for running NMR experiments
  • NMR Basics
  • Overview of the Basics of NMR Theory
  • NMR Magnet Destruction
  • See our presentation of the slicing open of a JEOL Delta-GSX 270 MHz NMR Magnet
  • Media

    Corona - Glow Discharge (DART Ion Source)

    January 28, 2022
    2637
      JEOL USA, Inc.
      11 Dearborn Road
      Peabody, MA 01960
      © Copyright 2022 by JEOL USA, Inc.
      Terms of Use
      |
      Privacy Policy
      |
      Cookie Preferences