JEOL Resources

Documentation in support of your JEOL product.

GC/MS and LC/MS Analysis of Endocrine Disruptors

Several chemical compounds that are widely distributed in the environment have been found to possess hormone-mimicking activities. These compounds have been found to interfere with hormonal activity through a variety of mechanisms, and they may have adverse effects on the health of animals and humans. Terms used to describe these compounds include endocrine disruptors, hormone disruptors, and estrogen mimickers. Classes of compounds believed to have hormone-disrupting effects include phthalates (plasticizers), alkyphenols (detergents), organochlorine pesticides, PCBs, dioxins, and food packaging chemicals such as bisphenol A (BPA) and butylated hydroxyanisole (BHA). Efforts are underway in several countries to develop analytical methods for assessing the distribution of these compounds in the environment. In the US, the Environmental Protection Agency has established the Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC), and in Japan, the Environment Agency has organized the Environmental Endocrine Disruptor Group. We report the analysis of ppb-level samples of standard samples, river water and water from sewage treatment plants by both low-and high-resolution selected ion moniroting (SIM) mass spectrometry with benchtop GC/MS systems. We evaluate high- and low-resolution SIM with LC/MS methods as an alternative analytical approach that does not require derivatization.

14N decoupled 1H–19F HOESY with ROYALPROBE™ HFX_NM190012E

Fluorine and nitrogen containing organic compounds are often found in a variety of fields such as pharmaceutical and material sciences. Such compounds show unique properties based on their conformations and orientations, which are often induced by hydrogen bonds between N-H and F atoms. Therefore, analysis of molecular conformations and inter-molecular interactions are important. Here, we report 14N decoupled 1H–19F HOESY (hetero nuclear NOE) for fluroinated benzanilide (1) as a demonstration.

Other Resources

The following resources are available for the JEOL Analytical Instruments:


Corona - Glow Discharge (DART Ion Source)

February 22, 2020