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Application of HFX NMR to Facilitate the Complete Assignment of the Anti-fungal Agent Voriconazole

Fluorine is found with an ever-increasing frequency in materials science and both legal and illicit drugs [ref 1-5]. In this application note results are presented to illustrate the simplification afforded by the routine application of triple-resonance NMR to clearly assign voriconazole, a molecule containing proton, carbon, and nitrogen molecules with many atoms exhibiting J-coupling to fluorine. The HFX ROYAL probe is a completely new probe technology utilizing magnetic coupling to afford highly efficient HF-X tuning which can function as a simple switch to highest sensitivity dedicated 1H or 19F or very well balanced dual 1H/19F performance on demand. References 6-8 detail the technological developments for the HFX ROYAL probe.

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Corona - Glow Discharge (DART Ion Source)

February 22, 2020
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