Experimental Solid melamine granules were artificially spiked into commercially available dry nonfat milk at levels between 1000ppm and 500 ppb. These samples were then pulverized with a mortar and pestle to homogenize the mixtures. For analysis, the AccuTOF-DART system was set to the following parameters: needle voltage 3500V, discharge electrode 150V, grid electrode 40V, Helium temperature 150 degrees C, and He flowrate 2.3 L/min. A melting point tube was dipped and swirled through the melamine/milk mixture and then placed in the Helium stream between the DART and the AccuTOF atmospheric pressure interface. The data was collected in a matter of seconds from the moment the samples were introduced into the DART stream. A representative mass spectrum is shown in Figure 1 that shows the high resolution and isotopic data for the melamine [M+H]+. Additionally, a semi-quantitative calibration curve was constructed to show the ability of the AccuTOF-DART to measure melamine in dry milk over a dynamic range of concentrations (Figure 2). Furthermore, using this methodology, the AccuTOF-DART was able to detect 1 ppm of melamine in dry milk, which is below the United States Food and Drug Administration’s maximum allowable concentration of 2.5 ppm.