Analytical Instrument Documents

Qualitative analysis by combined gas chromatography and mass spectrometry (GC-MS) generally relies on database searching for electron ionization (EI) mass spectra. However, the molecular ion may be weak or absent in EI mass spectra. Chemical ionization (CI) is a widely used soft ionization method that can often provide molecular weight information that is lacking in the EI mass spectra. JEOL msFineAnalysis iQ software makes use of the integrated information from both EI and soft ionization GC-MS data for confident qualitative analysis.

The AccuTOF-DART Ambient Ionization Toolbox™ provides a variety of ambient ionization methods for rapid and convenient analysis of diverse compound types. Here, an isotopically labeled peptide was purchased from a vendor at a suspiciously low price. Inlet ionization with 3-nitrobenzonitrile matrix revealed that the sample did not contain the expected 13C and 15N labels. A separate sample of the isotopically labeled peptide from an alternate supplier showed the expected labeling.

DEP (Direct Exposure Probe) is a technique in which a sample is directly applied to a platinum filament at the tip of the probe and rapidly heated by applying an electric current to the filament. This method enables rapid ionization while minimizing thermal decomposition of the sample, thus requiring little to no complex sample pretreatment and making it suitable for the analysis of nonvolatile substances or those prone to thermal decomposition. In this study, therefore, a direct introduction method using DEP was applied, and the results of rapid qualitative analysis of organic pigments contained in the pigmented layer of an indoor line tape are reported.

In this study, a case was examined in which indoor line tape used for approximately eight months exhibited a degradation phenomenon where the color of the pigmented layer disappeared due to the influence of oblique light. The objective was to evaluate this oblique light-induced degradation and to clarify its underlying causes. For the evaluation, qualitative analysis of the substrate layer and adhesive layer constituting the tape was first carried out using the direct EGA-MS (Evolved Gas Analysis–Mass Spectrometry) method. This technique enabled direct detection of thermally decomposed products from each constituent layer, allowing for characterization of the material composition.

In this study, pyrolysis (Py)/GCxGC/HR-TOFMS system was applied to investigate the pyrolysis products of Vinylpyridine and Divinylbenzene copolymer as the ion exchange resin sample.

In this study, pyrolysis(Py)/GCxGC/HR-TOFMS system was applied to investigate the pyrolysis products of Ethylene-propylene–diene rubber (EPDM).

In this report, we analyzed methylephedrine, a phenethylamine compound, in common cold medicines as an application to the field of forensic chemistry.

In this work, commercially available organic pigments were analyzed using JMS-S3000 SpiralTOF™ and JMS-T200GC AccuTOF™ GCx-plus. Measurements were performed by matrix-free LDI (Laser Desorption Ionization) on the JMS-S3000 and by FD (Field Desorption) on the JMS-T200GC. Because good results were obtained with both methods, we report them here.

In this report, we will discuss the analysis of medicinal components in a combination cold remedy.

Matrix-assisted laser desorption/ionization (MALDI) combined with in-source decay (ISD) is a useful tool for doing top-down sequencing of intact proteins. In this work, we measured and compared the ISD fragment ions generated for several proteins using the high resolution MALDI- Spiral mode and the high sensitivity MALDI-Linear mode available on the JEOL SpiralTOF MALDI-MS system.