JEOL USA Press Releases

July 24, 2023, M&M 2023 Minneapolis, MN -- JEOL introduces two new Scanning Electron Microscopes this week at M&M 2023 in Minneapolis. The new SEMs incorporate the next level of intelligent technology and automation for ease of operation and fast, high-resolution imaging and analysis. These new-generation SEMs make it easy to acquire data for all specimen types.

Both new SEMs feature “Simple SEM” for automatic image collection at multiple locations, magnifications, and conditions, Live EDS analysis, Live 3D microscopy, automatic large-area analysis with ZeroMag software, Montage for large area mosaics, and automatic functions from alignment to focus for fast, clear, high-resolution images.

The new JSM-IT710HR SEM is a compact, versatile Schottky Field Emission SEM that delivers large probe currents while maintaining a small probe, making it ideally suited for higher resolution needs. A large specimen chamber and both High and Low Vacuum operation allow a wide variety of specimen types to be imaged and analyzed in their native state.

The new JSM-IT210 InTouchScope™ SEM is a compact microscope with easy, automated workflow features including Specimen Exchange mode that guides a new operator step-by-step from sample introduction to ideal imaging and analysis conditions.

JEOL has a complete range of Scanning Electron Microscopes ranging from the popular NeoScope tabletop SEM to its flagship ultrahigh resolution field emission SEM. JEOL offers applications and service support for all of its Electron Microscopes and scientific instruments, with over 70 years of expertise in electron optics.

Peabody, MA – As many legacy NMR instruments are no longer eligible for service from major players that have exited the space, members of the scientific community are faced with a choice: Keep their magnet and upgrade their console to the latest software or buy an entirely new system.

Upgrading an existing NMR console outfits the instrument with the latest technology and yields increase performance identical to that of a new system. Because the lifespan of a magnet far outlasts the console operating the instrument, this is a great way to save on costs and make full use of their magnet.

\“Replacing the console on the older NMR system is an affordable option to get the most out of existing NMR setup since one will have an opportunity to use newer probes, sample changers and modern applications,” shares Dr. Timothy Bergeron. “This will expand the range of NMR methods one can use and it will improve sample-to-sample throughput.”

Fortunately, JEOL is offering an NMR Console Upgrade Initiative, which offers discounted pricing for qualifying instruments. Those who are curious to learn if they qualify for the program can check out the digital NMR Console Upgrade Guide.

JEOL, Ltd. began manufacturing and selling NMR instruments in 1959. JEOL USA, Inc., a wholly owned subsidiary of JEOL, Ltd., Japan, was incorporated in the United States in 1962. The company has 13 regional service centers that offer unlimited emergency service and support in the U.S.

Peabody and Andover, MA - Two towering JEOL Electron Microscopes stand ready to produce terabytes of valuable data for researchers at Generate:Biomedicines each day, who are accelerating drug discovery and development of novel therapeutics using machine learning and generative artificial intelligence. The two Transmission Electron Microscopes, the JEOL CRYO ARM 200 and CRYO ARM 300 are used in structural biology, and at Generate:Biomedicines they will be used to capture atomic resolution details of proteins that will help provide therapies in the fields of oncology, immunology, and infectious disease.

JEOL has completed installation of the two CRYO ARMs at Generate:Biomedicines’ laboratory space in Andover, Massachusetts. The new facility expands beyond the company’s Somerville, Mass headquarters to specifically house their microscopy labs. Generate:Biomedicines unveiled the new CryoEM facility in June. JEOL will provide dedicated applications support and continue to work closely with Generate:Biomedicines scientists to integrate the advanced microscopes into their fast-paced research programs. JEOL, with USA headquarters nearby in Peabody, MA and corporate headquarters in Akishma, Japan, has been producing cutting edge electron microscopes for more than 70 years, advancing technology that has important ramifications in the life sciences as well as the materials sciences. 

Adam Root, Vice-President of Protein Sciences at Generate:Biomedicines, is excited about how the CRYO ARMs will be used to computationally design biotherapeutics. “We’ve built this facility to perform CryoEM at scale, adding structure determination to our ‘build-test-learn’ cycle and to continually advance our computational protein generation capabilities,” he says.  Their process allows them to rapidly visualize, at the atomic scale, the binding of computationally-designed drug candidates to any disease target, he explains. Instead of relying on a purely trial-and-error solution to disease, they will be able to leverage this structural data to propose entirely new therapeutic protein solutions with intent. 

“We will be pushing the CryoEM envelope,” adds Ed Brignole, Senior Director of CryoEM, “The two biggest evolutions in structural biology are the result of CryoEM technology and machine learning for predicting and designing protein structure. We are at the intersection putting the two together.” 

In keeping with the mission at Generate:Biomedicines, Ed adds, “We’ve studied millions of proteins and learned the general rules by which nature encodes function. From this knowledge we can generate novel medicines with specific therapeutic functions. We call this breakthrough Generative Biology. This is a fundamental shift in what’s possible in the field of therapeutic development, and we are incredibly excited as we realize the breadth of its potential.”

CryoEM methodology has been successfully applied to study therapeutic targets such as viruses, membrane proteins, and components of the immune system. The ability to capture the structure of biomolecules with CryoEM is key in understanding how these protein systems function, or malfunction in the case of disease, as well as in identifying potential drug-binding targets for therapies. In the last decade, the field of structural biology was revolutionized with the advent of direct detector cameras and highly stable, automated cryogenic electron microscopes propelling CryoEM into becoming one of the most widely used tools in structural biology. The dramatic evolution of the method was celebrated in 2017 with the Nobel prize in Chemistry awarded to Richard Henderson, Jacques Dubochet and Joachim Frank for each of their contributions to the field.

Generate:Biomedicines was founded by Flagship Pioneering after two years of foundational research in its Labs unit and launched in 2020. The proximity of Generate:Biomedicines’ CRYO ARMs and JEOL’s USA headquarters lends itself naturally to cooperation between JEOL USA scientists who have ready access to the high-end research microscopes to understand their application in the field and to optimize their abilities. 

“Generate:Biomedicines’ goal and strategy is an unparalleled undertaking in the field of medicine. JEOL USA is extremely proud to be part of the journey that Generate:Biomedicines will undertake to develop novel therapeutics that will greatly benefit mankind” says Jaap Brink, CryoEM Product Manager at JEOL USA.
 

(Peabody, MA and Pittsburgh, PA) -- JEOL USA and Cumberland Additive, Inc. (CAI) are pleased to announce that Cumberland’s Neighborhood 91 facility in Pittsburgh will be the first installation in North America of JEOL’s new Electron Beam Melting (EBM) Powder Bed Fusion (PBF) system. This new metal 3D Printed E-Beam system will expand capabilities, primarily for serial production of parts.

CAI is a trusted AM leader who manufactures prototypes through serial production of parts, supporting the aerospace, defense, space, and energy markets. Additional services offered at Cumberland include DfAM (Design for Additive Manufacturing), engineering, post-processing and quality inspection. JEOL is a well-known leader in the field of electron optics. The company introduced the new E-beam metal 3D printer to the North American market at Rapid TCT in May 2022 and garnered much interest in its display of serially built nested parts and a lightweight yet strong titanium electron beam column, just a few examples of parts it has produced.

The collaboration between the two companies brings JEOL new opportunities to demonstrate the unique abilities of the new EBM system in a dedicated environment for Additive Manufacturing. Cumberland is an AS9100D & ITAR-certified company with established processes and procedures that meet rigorous serial production requirements.

“We are delighted to align with CAI’s existing customer base and expansion strategy with aerospace, medical, and energy industries, and to showcase the production quality and reliability of our 3D printer that will be centrally located at Neighborhood 91, the first fully integrated production campus dedicated to additive manufacturing,” said JEOL USA President Robert Pohorenec. “In addition to being a centralized resource for the AM industry, Neighborhood 91 attracts collaborative academic research opportunities and workforce development at world-class universities like Carnegie Mellon and University of Pittsburgh.

“The past year has been significant for JEOL’s Additive Manufacturing group in the US,” Pohorenec continued. “We are currently pursuing AM-specific aerospace Fusion-Based Metal Additive Manufacturing qualifications that will validate the robustness and reliability of JEOL designed hardware.” 

John Jenkins, President of Cumberland Additive emphasized this new partnership: ”Cumberland is excited to partner with JEOL to bring in this new state-of-the-art, electron beam technology that promises cost effective and efficient manufacturing, with a diversity of material offerings for our customers. We are honored to be the first North America partner location for this exciting new technology.”  

JEOL’s EBM 3D printing technology began in 2014, derived from the company’s decades-long expertise in the development and production of advanced electron optics technology used for research and industrial applications, including electron microscopes and e-beam lithography tools with unique vacuum technology. The JEOL EBM 3D printer is designed for serial production with maximum uptime. Emitter lifetime is guaranteed over 1500hrs, which will give CAI confidence in their ability to provide timely solutions to their customers. Another key differentiator in JEOL 3D printing technology is the EBM’s clean, helium-free production environment that prevents smoke events and powder scattering.  At this time the materials that can be printed are Ti6Al4V, Nickel Alloy 718, and pure copper.  

The key to keeping AM production running smoothly is a reliable manufacturing tool backed by timely on-site repair. In addition to its reliable performance, the new EBM system is supported by JEOL’s nationwide field service support group of over 180 engineers with an average of over 10yrs experience in electron optics and vacuum technology.

About Cumberland Additive, Inc.

Cumberland Additive, Inc. began as Directed Manufacturing, Inc. in 2006. The company achieved steady growth throughout multiple markets, expanding manufacturing capabilities from polymer prototyping to serial production of metals and polymers on mid and large-format printers. Under new ownership as of May 31, 2019, Cumberland Additive is showcasing our expertise in additive manufacturing, providing engineering services and turn-key production using Powder Bed Fusion Technology in metals and advanced polymers. Cumberland is advancing 3D Printing by building trust with our partners through proven additive manufacturing experience, and a laser focus on technical data that is supported by repeatable quality and on-time delivery. Learn more at CumberlandAdditive.com.

Peabody, MA – With more than 50 years of innovation in mass spectrometry, JEOL is once again pushing science a step further with their introduction of msFineAnalysis AI, an artificial intelligence-powered software designed to automatically perform qualitative GC-MS analysis.

msFineAnalysis AI offers a new structure analysis tool for unknowns that is specifically designed for the JEOL JMS- T2000GC “AccuTOF™ GC-Alpha.” This next-generation software adds this structure analysis capability to the automatic qualitative analysis functionality that was already available with our previous generation msFineAnalysis.

This software’s integrated analysis combines GC/EI high resolution data, GC/soft ionization high resolution data, and structure analysis using two AIs. These advanced AI technologies allow msFineAnalysis AI to provide a unique automatic structure analysis capability that was not previously available for GC-MS qualitative analysis.

Currently available GC-MS databases contain mass spectra for less than one million chemical compounds, a tiny fraction of the possible chemical structures.  Prior to the development of JEOL’s new software, identification of compounds that do not have entries in the mass spectral databases required a skilled chemist with significant knowledge, experience, and time.

In this AI-assisted workflow, deconvolution of GC-MS data into mass spectrum, library search, molecular ion search, accurate mass analysis, isotope pattern matching, and structural analysis can all happen within minutes.

This newly developed automated structural analysis software incorporates two different structure analysis tools: an in-silico database consisting of AI-generated EI mass spectra for the 100 million structures in the PubChem database, and a support AI that predicts the presence and absence of common substructures.

Applications scientist Dr. Chip Cody is particularly excited about what this software means for the scientific community as a whole, saying “Computer-aided determination of chemical structures from EI mass spectra and the reverse – prediction of EI mass spectra from chemical structures -- has been a goal since the 1960’s. This goal is finally achieved with JEOL’s development of msFineAnalysis AI.”

msFineAnalysis AI is available exclusively on JEOL’s 6^th-generation high resolution time-of-flight mass spectrometer (HRTOFMS), the AccuTOF GC-Alpha. This AI-powered software combined with increased mass resolving power (R=30,000), improved mass accuracy (≤ 1ppm), and multiple soft ionization sources, makes the GC Alpha an excellent choice for mass spectrometry labs exploring a variety of applications.

JEOL is a world leader in equipment and instrumentation for high-performance scientific and industrial research and development. Core product groups include electron microscopes (SEMs and TEMs), instruments for the semiconductor industry (electron beam lithography and a series of defect review and inspection tools), and analytical instruments including mass spectrometers, NMRs and ESRs.

JEOL USA, Inc., a wholly owned subsidiary of JEOL, Ltd., Japan, was incorporated in the United States in 1962.  The company has 13 regional service centers that offer unlimited emergency service and support in the U.S.

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If you would like more information on this topic, please call Nathan Phillips at +1 (978) 536-2271 or email at NPhillips@jeol.com.

Peabody, MA – Petrochemical analysis just got a little bit easier with the introduction of JEOL’s AccuTOF™ GC Alpha. A leader in the mass spectrometry space for over 60 years, this 6th-generation high resolution time-of-flight mass spectrometer (HRTOFMS) features increased mass resolving power (R=30,000), improved mass accuracy (≤ 1ppm), and multiple soft ionization sources, making it a strong choice for labs analyzing petroleum, gas, oil, and shale.

Furthermore, the GC-Alpha can be combined with comprehensive two-dimensional gas chromatography for GCxGC-HRTOFMS which is a powerful method for characterizing complex mixtures such as base oils. The system includes Electron Ionization (EI) for database searches, but this technique often lacks a strong molecular ion signal.
The GC-Alpha has optionally available Field Ionization (FI) and Field Desorption (FD) which are well suited for hydrocarbons analysis because they generate molecular ions for most compounds, including saturated hydrocarbons, with minimal fragmentation. The resulting mass spectra are dominated by molecular ions, whether from the GC output (FI) or from the emitter surface (FD).

“Soft ionization is essential for the qualitative analysis of unknown compounds as EI does not always produce a molecular ion,” says Dr. John Dane, Mass Spectrometry Product Manager at JEOL USA.  “Using soft ionization like FI in combination with the GC-Alpha’s high-resolution capabilities allows the analyst to also determine the molecular ion information.  Our optional combination EI/FI/FD ion source allows you to get the best of both worlds, while not having to break vacuum to switch between techniques.”
Structural elucidation of hydrocarbon classes in petroleum products are always in high demand. This instrument also features msFineAnalysis AI, a new artificial intelligence software designed to predict the molecular structure of an unknown analyte by using hard and soft ionization data together.

JEOL is a world leader in equipment and instrumentation for high-performance scientific and industrial research and development. Core product groups include electron microscopes (SEMs and TEMs), instruments for the semiconductor industry (electron beam lithography and a series of defect review and inspection tools), and analytical instruments including mass spectrometers, NMRs and ESRs.

JEOL USA, Inc., a wholly owned subsidiary of JEOL, Ltd., Japan, was incorporated in the United States in 1962.  The company has 13 regional service centers that offer unlimited emergency service and support in the U.S.  

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If you would like more information on this topic, please call Nathan Phillips at +1 (978) 536-2271 or email at NPhillips@jeol.com.
 

Peabody, MA – JEOL USA, Inc, a leader in the mass spectrometry space for over 60 years, has once again reimagined their single quadrupole instrument to meet the evolving needs of the scientific community. Officially termed the JMS-Q1600GC UltraQuad™ SQ-Zeta, this GC-Quadrupole Mass Spectrometer is equipped with high-performance capabilities for a wide variety of measurement and analysis needs.

JEOL’s UltraQuad™ SQ-Zeta provides a high-performance advantage through bringing together advanced mass spectrometry technology. Equipped with the largest hyperbolic-shaped quadrupole in its class, this design allows for a wider dynamic range from a much larger ion volume, as well as high sensitivity due to efficient ion transmission. Additionally, scientists can perform a range of experiments by leveraging photoionization (PI), chemical ionization (CI), and high sensitivity EI ion sources that are optionally available for this instrument.

To help with data analysis, the SQ-Zeta also includes a unique software package msFineAnalysis iQ for automatic data analysis. More specifically, msFineAnalysis iQ provides automatic peak deconvolution, data alignment between EI and soft ionization (CI, PI) data, molecular ion identification, and database searches.

“Having a benchtop system that offers not only EI for database searches but also soft ionization for molecular ion identification is essential for analysis of unknowns” says product manager, Dr. John Dane. “The addition of msFineAnalysis iQ to our system takes the instrument capabilities a step further by streamlining the overall data analysis by automatically processing the data into a color-coded report that simplifies the analyst’s job for determining what is present in their samples.”

The versatility of the SQ-Zeta sets it apart as a clear choice for academic or service-focused mass spectrometry labs. From quantitative applications such as environmental samples, water quality control and agrochemicals, to qualitative applications such as materials and aroma analyses, this entry level workhorse instrument can do it all.

JEOL is a world leader in equipment and instrumentation for high-performance scientific and industrial research and development. Core product groups include electron microscopes (SEMs and TEMs), instruments for the semiconductor industry (electron beam lithography and a series of defect review and inspection tools), and analytical instruments including mass spectrometers, NMRs and ESRs.

JEOL fully entered the QMS market with the launch of JMS-AM Series AUTOMASS in 1989. Since 1989, the system and hardware have been continuously upgraded, leading to the release of the 5th generation GC-QMS into the market (JMS-Q1500GC) in 2016. Now JEOL has introduced the 6th generation GC-QMS, succeeding the technologies that were cultivated in its predecessors with additional upgraded functionality.

JEOL USA, Inc., a wholly owned subsidiary of JEOL, Ltd., Japan, was incorporated in the United States in 1962.  The company has 13 regional service centers that offer unlimited emergency service and support in the U.S.

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If you would like more information on this topic, please call Nathan Phillips at +1 (978) 536-2271 or email at NPhillips@jeol.com.

(February 7, 2023 Peabody, Mass.) --  JEOL Electron Microscopes, Nuclear Magnetic Resonance Spectrometers, and Mass Spectrometers are used for research in nearly every scientific discipline including life sciences, materials science, forensics, and drug discovery.  At Pittcon 2023 (March 18-22), JEOL will focus on “The Science of Energy” with specialized imaging and analysis solutions for researchers who are developing battery materials, including Lithium-ion batteries. JEOL technology is also helping researchers to improve petroleum, solar, and catalysis products. 

Energy Storage - Developing and Improving Lithium Ion Batteries 

Microscopy Solutions - With demand for renewable energy sources and electric vehicles continuing to rise, there is an increasing need for reliable, high-capacity energy storage. Lithium-ion batteries (LIB) are ideal for this purpose but understanding the microstructural features and in particular the behavior of the light element Lithium is necessary to influence battery performance. JEOL has developed an air-isolated microscopy workflow that is proving its value in advanced battery research and production today.   

NMR Solutions - NMR is one of the few analytical methods that can directly observe Li ions and is a powerful tool for characterizing local structure and ion dynamics of LIB materials. JEOL solutions include solid-state NMR, in-situ NMR, and diffusion NMR with techniques tailored for the materials to be analyzed.

Petroleum Analysis – Detecting Hydrocarbons

Mass Spectrometry Solutions - For petroleum and petrochemical analyses, JEOL’s new AccuTOF™ GC-Alpha gas chromatograph, a high-resolution time-of-flight mass spectrometer (GC-HRTOFMS) is capable of differentiating various classes of hydrocarbons by using their exact masses. Additionally, optional soft ionization methods can be used for unambiguous detection of hydrocarbon molecular ions. JEOL’s new GC-HRTOFMS simultaneously accomplishes high mass-resolution analysis, high mass accuracy, and high-speed data acquisition, satisfying all your needs for petroleum and petrochemical analyses. 

See JEOL in Booth 2222 at Pittcon 2023. Learn more about JEOL energy solutions.

February 1, 2023 – Peabody, MA

JEOL has developed a new Focused Ion Beam (FIB) solution for preparation of specimens prior to observation in the Transmission Electron Microscope (TEM). The new JIB-PS500i is a multipurpose FIB-SEM that delivers the synergy of fast sample preparation, SEM imaging and EDS analysis in a single instrument.

High Quality Fast TEM Sample Preparation

The new FIB sample stage offers fast transitioning between processing and imaging, allowing for real-time feedback of specimen quality. With the ability to prepare samples thinner than 30nm, the FIB-SEM produces a sample suitable for superior atomic resolution imaging and analysis with STEM (Scanning Transmission Electron Microscope). A retractable STEM detector enables easy acquisition of bright field and dark field images during processing to precisely evaluate preparation of the TEM sample. The operator can easily prepare TEM specimens using the STEMPLING2 automatic TEM specimen preparation system, which allows unattended preparation of multiple samples.  

A specially designed double-tilt sample holder, TEM-Linkage, enables seamless transfer from the FIB-SEM directly to the TEM. 

New Large Chamber/Stage for Ultimate Sample Preparation Flexibility 

A key advantage of the JIB-PS500i FIB is the large specimen chamber with an easy-access door. This design supports an efficient workflow and flexibility for a variety of samples and processes. The 5-axis full-eucentric large motor stage is designed to transport both large and multiple samples in the XY direction, and at a wide stage tilt and rotation range. 

New FIB Column with higher current and superior performance at low kV

A new high current (up to 100 nA) FIB column is especially effective for large-area processing and analysis, which is ideal for semiconductor samples. The new FIB has high performance fine milling capabilities essential for quality lamella preparation imaging, EDS analysis, and 3D microscopy. The new JIB-PS500i has superior performance in the low kV range, as low as 0.5kV, essential for beam sensitive materials. 

The JEOL AccuTOF™-DART® 4G mass spectrometer has been chosen as one of the key technologies in a new mobile laboratory developed by the US Fish and Wildlife Service.  The new lab was officially christened on November 3, 2022 at the Clark R. Bavin National Fish and Wildlife Forensics Laboratory in Ashland Oregon.¹

The new laboratory, nicknamed “The Woodshed”, was constructed to carry out timber analyses at ports of entry. It will be used to identify illegally traded timber from endangered species and facilitate the legal timber trade. The laboratory, designed by the staff of the National Fish and Wildlife Forensic Lab, features the AccuTOF-DART mass spectrometer, a visual comparator, X-ray fluorescence (XRF) and laser-induced breakdown spectroscopy (LIBS) systems for elemental analysis, and 240V generator for off-grid analysis.

Ambient ionization, a key technology of the JEOL AccuTOF™-DART® 4G mass spectrometer, provides a unique benefit to this lab. The instrument pushes ionized gas particles through an open chamber to identify the molecular structure of any object that passes through the ionized stream. For scientists using this instrument in “The Woodshed”, this means they save time by skipping the sample preparation process, allowing them to process and identify greater quantities of illegally traded timber.

The AccuTOF™-DART® 4G DART was invented in 2003 by Dr. Robert “Chip” Cody of JEOL USA. JEOL is a world leader in manufacturing equipment and instrumentation for demanding scientific and industrial research and development. Core product groups include analytical instruments including mass spectrometers, NMRs, and ESRs and electron microscopes (SEMs and TEMs).

¹https://www.fws.gov/law-enforcement/clark-r-bavin-national-fish-and-wildlife-forensics-laboratory)