INADEQUATE measurement using SuperCOOL probe It is often difficult to unambiguously determine structures of molecules, which have many non-protonated carbon atoms. Because such compounds contain quaternary carbons, lack protons and bonding to quaternary carbons each other, HMBC (Heteronuclear Multiple Bond Correlation) experiment cannot provide long-range 1H-13C connectivity. Therefore, INADEQUATE (Incredible Natural Abundance DoublE QUAntum Transfer Experiment), which is 13C-13C correlation experiment at natural 13C abundance, represents a powerful tool for proton-diluted compounds. July 28, 2020 Nuclear Magnetic Resonance (NMR), SuperCOOL Probe 0 Comment Read More >>
Visualization of hydrogen-bonding: Electron and NMR nano-crystallography_NM190004 Here, we combine ED and solid-state NMR through the first principle quantum computation with the NMR crystallography approach for crystalline structure solution. The method, electron and NMR nano-crystallography, can be applied to nano- to micro-crystals even for mixture samples. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR, Yokogushi (Cross-platform Analysis) 0 Comment Read More >>
Spectral Separation of mixtures by solid state NMR_NM180015E Solid state NMR is a powerful tool to obtain information in the crystalline state which would be lost in the solution state. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
A 1H Solid State NMR Application for Pharmaceutical Development by using Ultra Fast MAS: Drug-Polymer Intermolecular Interaction on Solid Dispersions_NM190003E The low oral bioavailability of a drug due to its poor aqueous solubility is a major challenge for pharmaceutical development. Solid dispersion (SD), where the amorphous drug is dispersed into the polymer matrix, is one of the useful approaches to improve the aqueous solubility. However, thermodynamically unstable nature of an amorphous drug increases its susceptibility to recrystallize upon storage, which, in turn, reduces its solubility and dissolution. Therefore, design of thermodynamically stable SD is required. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
Overtone solid-state NMR spectroscopy on Nitrogen-14_NM180002E 15N NMR is widely used because of the importance of nitrogen in chemistry, materials, biology, environment, etc. However, very low abundance of 15N (<0.4%) results in poor sensitivity and thus makes observation time-consuming. On the other hand, the rest of nitrogen atoms are also NMR sensitive nucleus of 14N. Despite the high abundance of 14N (>99%), it's application is rather limited due to the huge quadrupolar interactions and its spin quantum number I = 1. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
AUTOMAS: Efficient time management in solid state NMR_NM180003E JEOL AUTOMAS probe combined with Auto Sample Changer and Auto Tune Unit allows for fully automated solid NMR measurements including sample load/eject, tuning and matching, magic angle spinning frequency control, and temperature control. This enables you to manage efficient data collection as liquid NMR. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
2.5 / 3.2 / 4.0 mm XY-MAS probe We can supply 2.5, 3.2 or 4.0 mm XY-MAS probes suitable for inorganic materials. The XY-MAS probe has two rf channels which enable simultaneous strong rf-field irradiation. July 28, 2020 Nuclear Magnetic Resonance (NMR), Solid State NMR 0 Comment Read More >>
14N decoupled HETCOR for 19F-mediated amide hydrogen bonds with ROYALPROBE™ HFX_NM190011E Fluorine and nitrogen containing organic compounds are often found in a variety of fields such as pharmaceutical and material sciences. Such compounds show unique properties based on their conformations and orientations, which are often induced by hydrogen bonds between N-H and F atoms. Therefore, analysis of molecular conformations and inter-molecular interactions are important. Here, we report 14N decoupled 1H-19F HETCOR as an example of hydrogen bonds analysis between N-H and F for fluorinated benzanilide as a demonstration. July 28, 2020 Nuclear Magnetic Resonance (NMR), ROYALPROBE HFX 0 Comment Read More >>
Utilities of No-D NMR (No-Deuterium Proton NMR) No-D NMR (No-Deuterium Proton NMR) technique is a measurement of high resolution 1H NMR spectra without deuterium solvent. It suggests that any reaction mixture or reagent solution are directly available for No-D NMR measurement. July 28, 2020 No-D NMR (No-Deuterium Proton NMR), Nuclear Magnetic Resonance (NMR) 0 Comment Read More >>
On Accurate Measurements of Diffusion Coefficients by PGSE NMR Methods In this article, we will show the accurate measurements of the diffusion coefficients (D) by using room-temperature ionic liquids (RTIL, IL) as examples. July 28, 2020 Experimental Possibilities, Nuclear Magnetic Resonance (NMR) 0 Comment Read More >>