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• JMS-S3000 SpiralTOF Applications Notebook

  Includes 32 application notes in the following categories: Introduction and Fundamentals, Synthetic Polymers, Small Molecules, Lipids, Peptides and Proteins, Other biomolecules (natural products, oligosaccharides), and JMS-S3000 SpiralTOF bibliography
• JMS-S3000 SpiralTOF™-plus Product Brochure

  The JMS-S3000 SpiralTOF™-plus Ultra-High Mass Resolution MALDI-TOFMS System time-of-flight optics design utilizes a figure-eight ion trajectory to allow a 17m flight path to fit in an extremely small console. This exceptionally long flight path results in an ultrahigh resolving power of >75,000 and sub-ppm mass accuracy. The versatile SpiralTOF is an essential research tool for your state-of-the-art MS analyses of functional synthetic polymers, material science and biomolecules.
• High Mass Resolution MALDI-imaging MS Using JMS-S3000 SpiralTOF and msMicroImager

  Imaging mass spectrometry using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-Imaging) has been expanded during the last decade in biological applications, to assess the distribution of proteins, peptides, lipids, drugs, and metabolites in a tissue specimen. In MALDI-Imaging measurements, a laser irradiation point was scanned on a sample surface to acquire a mass spectrum at each point. Analyzing the mass spectra with two-dimensional position information, localization of compounds with inherent molecular weights can be visualized or the mass spectra for certain regions of interests (ROIs) can be created. The JMS-S3000 SpiralTOF (Fig. 1) is a MALDI-TOFMS, which utilizes the JEOL patented spiral ion optical system. It has a 5-10 times longer flight path than the typical reflectron type MALDI-TOFMS. As a result, it can achieve high mass-resolution to separate peaks that have the same nominal mass but have different exact masses (isobaric separation). On the other hand, there are some issues for analyzing high mass resolution and high lateral resolution MALDI-Imaging raw data with common imaging software options such as Biomap.
• Imaging mass spectrometry using JMS-S3000 SpiralTOF™

  SpiralTOF is the world’s highest mass resolution MALDI-TOFMS adopting JEOL’s own ion optical system. Features of SpiralTOF for Imaging mass spectrometry (IMS): Ultra-high mass resolution; Low chemical background noise. (Elimination of PSD ions); High Stability of Peak Position during IMS Measurement
• Comparison of the JMS-S3000 SpiralTOF-TOF and a 4-Sector Tandem Double-Focusing Mass Spectrometer

  The JMS-3000 SpiralTOF™ has an optional TOF-TOF mode that features monoisotopic precursor ion selectivity, elimination of post source decay (PSD) ions, and high energy collision induced dissociation (CID). The JMS-700T MStation four-sector tandem double focusing mass spectrometer, although featuring a different analyzer and ionization techniques, has similar capabilities that have been previously used for a wide variety of applications including the structural analysis of complex biological molecules. In this work, we compare the SpiralTOF-TOF with the MStation four sector tandem double focusing mass spectrometer using the same sample for MS/MS analysis.
• SpiralTOF Imaging Applications Notebook 2020

  Applications concerning MALDI MS Imaging using the SpiralTOF.