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• JMS-S3000 SpiralTOF LC-MALDI applications

  The JMS-S3000 SpiralTOF MALDI-TOF/TOF system offers outstanding LC-MALDI capabilities with the highest commercially available mass resolving power. Its standard control software has a number of new features, allowing for 1D visualization and analysis of the mass spectra measured for HPLC and SEC fractions collected for each analyte at equal intervals.The JMS-S3000 is a powerful analytical tool, suitable for rapidly changing research needs in areas such as synthetic polymers, material science, and biological polymers.
• JMS-S3000 SpiralTOF™-plus Product Brochure

  The JMS-S3000 SpiralTOF™-plus Ultra-High Mass Resolution MALDI-TOFMS System time-of-flight optics design utilizes a figure-eight ion trajectory to allow a 17m flight path to fit in an extremely small console. This exceptionally long flight path results in an ultrahigh resolving power of >75,000 and sub-ppm mass accuracy. The versatile SpiralTOF is an essential research tool for your state-of-the-art MS analyses of functional synthetic polymers, material science and biomolecules.
• High Mass Resolution MALDI-imaging MS Using JMS-S3000 SpiralTOF and msMicroImager

  Imaging mass spectrometry using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-Imaging) has been expanded during the last decade in biological applications, to assess the distribution of proteins, peptides, lipids, drugs, and metabolites in a tissue specimen. In MALDI-Imaging measurements, a laser irradiation point was scanned on a sample surface to acquire a mass spectrum at each point. Analyzing the mass spectra with two-dimensional position information, localization of compounds with inherent molecular weights can be visualized or the mass spectra for certain regions of interests (ROIs) can be created. The JMS-S3000 SpiralTOF (Fig. 1) is a MALDI-TOFMS, which utilizes the JEOL patented spiral ion optical system. It has a 5-10 times longer flight path than the typical reflectron type MALDI-TOFMS. As a result, it can achieve high mass-resolution to separate peaks that have the same nominal mass but have different exact masses (isobaric separation). On the other hand, there are some issues for analyzing high mass resolution and high lateral resolution MALDI-Imaging raw data with common imaging software options such as Biomap.
• Imaging mass spectrometry using JMS-S3000 SpiralTOF™

  SpiralTOF is the world’s highest mass resolution MALDI-TOFMS adopting JEOL’s own ion optical system. Features of SpiralTOF for Imaging mass spectrometry (IMS): Ultra-high mass resolution; Low chemical background noise. (Elimination of PSD ions); High Stability of Peak Position during IMS Measurement
• Comparison of the JMS-S3000 SpiralTOF-TOF and a 4-Sector Tandem Double-Focusing Mass Spectrometer

  The JMS-3000 SpiralTOF™ has an optional TOF-TOF mode that features monoisotopic precursor ion selectivity, elimination of post source decay (PSD) ions, and high energy collision induced dissociation (CID). The JMS-700T MStation four-sector tandem double focusing mass spectrometer, although featuring a different analyzer and ionization techniques, has similar capabilities that have been previously used for a wide variety of applications including the structural analysis of complex biological molecules. In this work, we compare the SpiralTOF-TOF with the MStation four sector tandem double focusing mass spectrometer using the same sample for MS/MS analysis.
• Structural analysis of melatonin and related compounds using JMS-S3000 SpiralTOFTM with the TOF-TOF option

  The JMS-S3000 SpiralTOF™, which has a JEOL-patented spiral orbital ion optical system, has a long-flight distance of 17 m and can achieve high-mass resolution. In addition, the electrostatic sectors that constitute the ion optical system can exclude PSD ions, making it possible to acquire a mass spectrum that is less affected by background ions. These features enable accurate mass measurement even in LMW regions[1].